Luteolin attenuates Wnt signaling via upregulation of FZD6 to suppress prostate cancer stemness revealed by comparative proteomics

The mechanisms underlying luteolin-induced inhibition of prostate cancer (PCa) stemness have remained elusive. Here, we report that luteolin suppresses PCa stemness through Wnt signaling by upregulation of FZD6 (frizzled class receptor 6). Luteolin inhibits PCa cell proliferation, migration, self-re...

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Detalles Bibliográficos
Autores principales: Han, Kun, Lang, Tingyuan, Zhang, Zhiqi, Zhang, Yi, Sun, Yongning, Shen, Zan, Beuerman, Roger W., Zhou, Lei, Min, Daliu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986741/
https://www.ncbi.nlm.nih.gov/pubmed/29867083
http://dx.doi.org/10.1038/s41598-018-26761-2

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