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Protein kinase Cε regulates nuclear translocation of extracellular signal-regulated kinase, which contributes to bradykinin-induced cyclooxygenase-2 expression

The proinflammatory mediator bradykinin stimulated cyclooxygenase-2 (COX-2) expression and subsequently prostaglandin E(2) synthesis in dermal fibroblasts. The involvement of B2 receptors and Gαq in the role of bradykinin was suggested by using pharmacological inhibitors. The PKC activator PMA stimu...

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Detalles Bibliográficos
Autores principales:	Nakano, Rei, Kitanaka, Taku, Namba, Shinichi, Kitanaka, Nanako, Sugiya, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986758/ https://www.ncbi.nlm.nih.gov/pubmed/29867151 http://dx.doi.org/10.1038/s41598-018-26473-7

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