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The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness
Stiffening of the aorta is an important independent risk factor for myocardial infarction and stroke. Yet its genetics is complex and little is known about its molecular drivers. We have identified for the first time, tagSNPs in the genes for extracellular matrix proteins, aggrecan and fibulin-1, th...
Autores principales: | Yasmin, Maskari, Raya Al, McEniery, Carmel M., Cleary, Sarah E., Li, Ye, Siew, Keith, Figg, Nichola L., Khir, Ashraf W., Cockcroft, John R., Wilkinson, Ian B., O’Shaughnessy, Kevin M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986773/ https://www.ncbi.nlm.nih.gov/pubmed/29867203 http://dx.doi.org/10.1038/s41598-018-25851-5 |
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