Cargando…
Combined Rho-kinase inhibition and immunogenic cell death triggers and propagates immunity against cancer
Activation of T cell immune response is critical for the therapeutic efficacy of cancer immunotherapy. Current immunotherapies have shown remarkable clinical success against several cancers; however, significant responses remain restricted to a minority of patients. Here, we show a therapeutic strat...
Autores principales: | Nam, Gi-Hoon, Lee, Eun Jung, Kim, Yoon Kyoung, Hong, Yeonsun, Choi, Yoonjeong, Ryu, Myung-Jeom, Woo, Jiwan, Cho, Yakdol, Ahn, Dong June, Yang, Yoosoo, Kwon, Ick-Chan, Park, Seung-Yoon, Kim, In-San |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986820/ https://www.ncbi.nlm.nih.gov/pubmed/29867097 http://dx.doi.org/10.1038/s41467-018-04607-9 |
Ejemplares similares
-
Xenogenization of tumor cells by fusogenic exosomes in tumor microenvironment ignites and propagates antitumor immunity
por: Kim, Gi Beom, et al.
Publicado: (2020) -
In situ immunogenic clearance induced by a combination of photodynamic therapy and rho-kinase inhibition sensitizes immune checkpoint blockade response to elicit systemic antitumor immunity against intraocular melanoma and its metastasis
por: Kim, Seohyun, et al.
Publicado: (2021) -
Degradation of tumour stromal hyaluronan by small extracellular vesicle-PH20 stimulates CD103(+) dendritic cells and in combination with PD-L1 blockade boosts anti-tumour immunity
por: Hong, Yeonsun, et al.
Publicado: (2019) -
Statin-mediated inhibition of RAS prenylation activates ER stress to enhance the immunogenicity of KRAS mutant cancer
por: Nam, Gi-Hoon, et al.
Publicado: (2021) -
Extracellular vesicles as a platform for membrane-associated therapeutic protein delivery
por: Yang, Yoosoo, et al.
Publicado: (2018)