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Differences between immunodeficient mice generated by classical gene targeting and CRISPR/Cas9-mediated gene knockout

Immunodeficient mice are widely used for pre-clinical studies to understand various human diseases. Here, we report the generation of four immunodeficient mouse models using CRISPR/Cas9 system without inserting any foreign gene sequences such as Neo(R) cassettes and their characterization. By elimin...

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Detalles Bibliográficos
Autores principales:	Lee, Jae Hoon, Park, Jong-Hyung, Nam, Tae-Wook, Seo, Sun-Min, Kim, Jun-Young, Lee, Han-Kyul, Han, Jong Hyun, Park, Song Yi, Choi, Yang-Kyu, Lee, Han-Woong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2018
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986857/ https://www.ncbi.nlm.nih.gov/pubmed/29594927 http://dx.doi.org/10.1007/s11248-018-0069-y

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