Self-Delivering RNAi Targeting PD-1 Improves Tumor-Specific T Cell Functionality for Adoptive Cell Therapy of Malignant Melanoma

Adoptive cell therapy (ACT) is becoming a prominent alternative therapeutic treatment for cancer patients relapsing on traditional therapies. In parallel, antibodies targeting immune checkpoint molecules, such as cytotoxic-T-lymphocyte-associated antigen 4 (CTLA-4) and cell death protein 1 pathway (...

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Detalles Bibliográficos
Autores principales: Ligtenberg, Maarten A., Pico de Coaña, Yago, Shmushkovich, Taisia, Yoshimoto, Yuya, Truxova, Iva, Yang, Yuan, Betancur-Boissel, Monica, Eliseev, Alexey V., Wolfson, Alexey D., Kiessling, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986970/
https://www.ncbi.nlm.nih.gov/pubmed/29735366
http://dx.doi.org/10.1016/j.ymthe.2018.04.015

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