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Review of various treatment options and potential therapies for osteonecrosis of the femoral head

Size and location of the lesion, subchondral collapse occurrence, and articular cartilage involvement are general disease progression criteria for direct osteonecrosis of the femoral head (ONFH) classifications. Treatment options for ONFH are usually based on individual factors and lesion characteri...

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Autores principales: Cao, Huijuan, Guan, Hanfeng, Lai, Yuxiao, Qin, Ling, Wang, Xinluan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Speaking Orthopaedic Society 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987013/
https://www.ncbi.nlm.nih.gov/pubmed/30035066
http://dx.doi.org/10.1016/j.jot.2015.09.005
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author Cao, Huijuan
Guan, Hanfeng
Lai, Yuxiao
Qin, Ling
Wang, Xinluan
author_facet Cao, Huijuan
Guan, Hanfeng
Lai, Yuxiao
Qin, Ling
Wang, Xinluan
author_sort Cao, Huijuan
collection PubMed
description Size and location of the lesion, subchondral collapse occurrence, and articular cartilage involvement are general disease progression criteria for direct osteonecrosis of the femoral head (ONFH) classifications. Treatment options for ONFH are usually based on individual factors and lesion characteristics. Although spontaneous repair of ONFH occurs in some cases, untreated ONFH is unlikely to escape the fate of subchondral collapse and usually ends up with total hip arthroplasty. Operations to preserve the femoral head, e.g., core decompression and bone grafting, are usually recommended in younger patients. They are helpful to relieve pain and improve function in the affected femoral head without subchondral collapse, however, poor prognosis after surgical procedures remains the major problem for ONFH. Pharmacological and physical therapies only work in the early stage of ONFH and have also been recommended as a supplement or prevention treatment for osteonecrosis. Following advances in basic science, many new insights focus on bone tissue engineering to optimize therapies and facilitate prognosis of ONFH. In this review, disease classifications, current treatment options, potential therapies, and the relevant translational barriers are reviewed in the context of clinical application and preclinical exploration, which would provide guidance for preferable treatment options and translation into novel therapies.
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spelling pubmed-59870132018-07-20 Review of various treatment options and potential therapies for osteonecrosis of the femoral head Cao, Huijuan Guan, Hanfeng Lai, Yuxiao Qin, Ling Wang, Xinluan J Orthop Translat Review Article Size and location of the lesion, subchondral collapse occurrence, and articular cartilage involvement are general disease progression criteria for direct osteonecrosis of the femoral head (ONFH) classifications. Treatment options for ONFH are usually based on individual factors and lesion characteristics. Although spontaneous repair of ONFH occurs in some cases, untreated ONFH is unlikely to escape the fate of subchondral collapse and usually ends up with total hip arthroplasty. Operations to preserve the femoral head, e.g., core decompression and bone grafting, are usually recommended in younger patients. They are helpful to relieve pain and improve function in the affected femoral head without subchondral collapse, however, poor prognosis after surgical procedures remains the major problem for ONFH. Pharmacological and physical therapies only work in the early stage of ONFH and have also been recommended as a supplement or prevention treatment for osteonecrosis. Following advances in basic science, many new insights focus on bone tissue engineering to optimize therapies and facilitate prognosis of ONFH. In this review, disease classifications, current treatment options, potential therapies, and the relevant translational barriers are reviewed in the context of clinical application and preclinical exploration, which would provide guidance for preferable treatment options and translation into novel therapies. Chinese Speaking Orthopaedic Society 2015-10-24 /pmc/articles/PMC5987013/ /pubmed/30035066 http://dx.doi.org/10.1016/j.jot.2015.09.005 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Cao, Huijuan
Guan, Hanfeng
Lai, Yuxiao
Qin, Ling
Wang, Xinluan
Review of various treatment options and potential therapies for osteonecrosis of the femoral head
title Review of various treatment options and potential therapies for osteonecrosis of the femoral head
title_full Review of various treatment options and potential therapies for osteonecrosis of the femoral head
title_fullStr Review of various treatment options and potential therapies for osteonecrosis of the femoral head
title_full_unstemmed Review of various treatment options and potential therapies for osteonecrosis of the femoral head
title_short Review of various treatment options and potential therapies for osteonecrosis of the femoral head
title_sort review of various treatment options and potential therapies for osteonecrosis of the femoral head
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987013/
https://www.ncbi.nlm.nih.gov/pubmed/30035066
http://dx.doi.org/10.1016/j.jot.2015.09.005
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