Stress-Induced Functional Alterations in Amygdala: Implications for Neuropsychiatric Diseases

The amygdala plays a major role in the processing of physiologic and behavioral responses to stress and is characterized by gamma-aminobutyric acid (GABA)-mediated high inhibitory tone under resting state. Human and animal studies showed that stress lead to a hyperactivity of amygdala, which was acc...

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Autores principales: Zhang, Xin, Ge, Tong tong, Yin, Guanghao, Cui, Ranji, Zhao, Guoqing, Yang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987037/
https://www.ncbi.nlm.nih.gov/pubmed/29896088
http://dx.doi.org/10.3389/fnins.2018.00367
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author Zhang, Xin
Ge, Tong tong
Yin, Guanghao
Cui, Ranji
Zhao, Guoqing
Yang, Wei
author_facet Zhang, Xin
Ge, Tong tong
Yin, Guanghao
Cui, Ranji
Zhao, Guoqing
Yang, Wei
author_sort Zhang, Xin
collection PubMed
description The amygdala plays a major role in the processing of physiologic and behavioral responses to stress and is characterized by gamma-aminobutyric acid (GABA)-mediated high inhibitory tone under resting state. Human and animal studies showed that stress lead to a hyperactivity of amygdala, which was accompanied by the removal of inhibitory control. However, the contribution of hyperactivity of amygdala to stress-induced neuropsychiatric diseases, such as anxiety and mood disorders, is still dubious. In this review, we will summarize stress-induced various structural and functional alterations in amygdala, including the GABA receptors expression, GABAergic transmission and synaptic plasticity. It may provide new insight on the neuropathologic and neurophysiological mechanisms of neuropsychiatric diseases.
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spelling pubmed-59870372018-06-12 Stress-Induced Functional Alterations in Amygdala: Implications for Neuropsychiatric Diseases Zhang, Xin Ge, Tong tong Yin, Guanghao Cui, Ranji Zhao, Guoqing Yang, Wei Front Neurosci Neuroscience The amygdala plays a major role in the processing of physiologic and behavioral responses to stress and is characterized by gamma-aminobutyric acid (GABA)-mediated high inhibitory tone under resting state. Human and animal studies showed that stress lead to a hyperactivity of amygdala, which was accompanied by the removal of inhibitory control. However, the contribution of hyperactivity of amygdala to stress-induced neuropsychiatric diseases, such as anxiety and mood disorders, is still dubious. In this review, we will summarize stress-induced various structural and functional alterations in amygdala, including the GABA receptors expression, GABAergic transmission and synaptic plasticity. It may provide new insight on the neuropathologic and neurophysiological mechanisms of neuropsychiatric diseases. Frontiers Media S.A. 2018-05-29 /pmc/articles/PMC5987037/ /pubmed/29896088 http://dx.doi.org/10.3389/fnins.2018.00367 Text en Copyright © 2018 Zhang, Ge, Yin, Cui, Zhao and Yang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhang, Xin
Ge, Tong tong
Yin, Guanghao
Cui, Ranji
Zhao, Guoqing
Yang, Wei
Stress-Induced Functional Alterations in Amygdala: Implications for Neuropsychiatric Diseases
title Stress-Induced Functional Alterations in Amygdala: Implications for Neuropsychiatric Diseases
title_full Stress-Induced Functional Alterations in Amygdala: Implications for Neuropsychiatric Diseases
title_fullStr Stress-Induced Functional Alterations in Amygdala: Implications for Neuropsychiatric Diseases
title_full_unstemmed Stress-Induced Functional Alterations in Amygdala: Implications for Neuropsychiatric Diseases
title_short Stress-Induced Functional Alterations in Amygdala: Implications for Neuropsychiatric Diseases
title_sort stress-induced functional alterations in amygdala: implications for neuropsychiatric diseases
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987037/
https://www.ncbi.nlm.nih.gov/pubmed/29896088
http://dx.doi.org/10.3389/fnins.2018.00367
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