Gut–Brain Axis and Mood Disorder

Humans have over 100 trillion bacteria, highly abundant in the intestinal tract. Evidence suggests that intestinal microbiota is associated with the neuro-endocrine-immune pathways and can be associated with various mood disorders. This review summarizes findings from studies looking into neurobioch...

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Detalles Bibliográficos
Autores principales: Liu, Lu, Zhu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Psychiatry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987167/
https://www.ncbi.nlm.nih.gov/pubmed/29896129
http://dx.doi.org/10.3389/fpsyt.2018.00223
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author Liu, Lu
Zhu, Gang
author_facet Liu, Lu
Zhu, Gang
author_sort Liu, Lu
collection PubMed
description Humans have over 100 trillion bacteria, highly abundant in the intestinal tract. Evidence suggests that intestinal microbiota is associated with the neuro-endocrine-immune pathways and can be associated with various mood disorders. This review summarizes findings from studies looking into neurobiochemical, neuroendocrine, and neuroimmune system mechanisms of the gut–brain axis to determine the relationship between intestinal microbiota and mood disorders. The effect of prebiotics, probiotics and antibiotics on mood disorders are also discussed, with the aim to propose some new therapeutic strategies for mood disorders.
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spelling pubmed-59871672018-06-12 Gut–Brain Axis and Mood Disorder Liu, Lu Zhu, Gang Front Psychiatry Psychiatry Humans have over 100 trillion bacteria, highly abundant in the intestinal tract. Evidence suggests that intestinal microbiota is associated with the neuro-endocrine-immune pathways and can be associated with various mood disorders. This review summarizes findings from studies looking into neurobiochemical, neuroendocrine, and neuroimmune system mechanisms of the gut–brain axis to determine the relationship between intestinal microbiota and mood disorders. The effect of prebiotics, probiotics and antibiotics on mood disorders are also discussed, with the aim to propose some new therapeutic strategies for mood disorders. Frontiers Media S.A. 2018-05-29 /pmc/articles/PMC5987167/ /pubmed/29896129 http://dx.doi.org/10.3389/fpsyt.2018.00223 Text en Copyright © 2018 Liu and Zhu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Liu, Lu
Zhu, Gang
Gut–Brain Axis and Mood Disorder
title Gut–Brain Axis and Mood Disorder
title_full Gut–Brain Axis and Mood Disorder
title_fullStr Gut–Brain Axis and Mood Disorder
title_full_unstemmed Gut–Brain Axis and Mood Disorder
title_short Gut–Brain Axis and Mood Disorder
title_sort gut–brain axis and mood disorder
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987167/
https://www.ncbi.nlm.nih.gov/pubmed/29896129
http://dx.doi.org/10.3389/fpsyt.2018.00223
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