Annexin A7 Levels Increase in Rats With Traumatic Brain Injury and Promote Secondary Brain Injury

The incidence of traumatic brain injury (TBI) has been increasing annually. Annexin A7 is a calcium-dependent phospholipid binding protein. It can promote melting of the cell membrane. Recent studies have shown that it plays an important role in atherosclerosis, other cardiovascular diseases, and a...

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Autores principales: Gao, Fan, Li, Di, Rui, Qin, Ni, Haibo, Liu, Huixiang, Jiang, Feng, Tao, Li, Gao, Rong, Dang, Baoqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987168/
https://www.ncbi.nlm.nih.gov/pubmed/29896083
http://dx.doi.org/10.3389/fnins.2018.00357
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author Gao, Fan
Li, Di
Rui, Qin
Ni, Haibo
Liu, Huixiang
Jiang, Feng
Tao, Li
Gao, Rong
Dang, Baoqi
author_facet Gao, Fan
Li, Di
Rui, Qin
Ni, Haibo
Liu, Huixiang
Jiang, Feng
Tao, Li
Gao, Rong
Dang, Baoqi
author_sort Gao, Fan
collection PubMed
description The incidence of traumatic brain injury (TBI) has been increasing annually. Annexin A7 is a calcium-dependent phospholipid binding protein. It can promote melting of the cell membrane. Recent studies have shown that it plays an important role in atherosclerosis, other cardiovascular diseases, and a variety of tumors. However, few studies of ANXA7 in TBI have been performed. We here observed how ANXA7 changes after TBI and discuss whether brain injury is associated with the use of ANXA7 antagonist intervention. Experimental Results: 1. After TBI, ANXA7 levels were higher than in the sham group, peaking 24 h after TBI. 2. The use of siA7 was found to reduce the expression of A7 in the injured brain tissue, and also brain edema, BBB damage, cell death, and apoptosis relative to the sham group. Conclusion: ANXA7 promotes the development of secondary brain injury (SBI) after TBI.
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spelling pubmed-59871682018-06-12 Annexin A7 Levels Increase in Rats With Traumatic Brain Injury and Promote Secondary Brain Injury Gao, Fan Li, Di Rui, Qin Ni, Haibo Liu, Huixiang Jiang, Feng Tao, Li Gao, Rong Dang, Baoqi Front Neurosci Neuroscience The incidence of traumatic brain injury (TBI) has been increasing annually. Annexin A7 is a calcium-dependent phospholipid binding protein. It can promote melting of the cell membrane. Recent studies have shown that it plays an important role in atherosclerosis, other cardiovascular diseases, and a variety of tumors. However, few studies of ANXA7 in TBI have been performed. We here observed how ANXA7 changes after TBI and discuss whether brain injury is associated with the use of ANXA7 antagonist intervention. Experimental Results: 1. After TBI, ANXA7 levels were higher than in the sham group, peaking 24 h after TBI. 2. The use of siA7 was found to reduce the expression of A7 in the injured brain tissue, and also brain edema, BBB damage, cell death, and apoptosis relative to the sham group. Conclusion: ANXA7 promotes the development of secondary brain injury (SBI) after TBI. Frontiers Media S.A. 2018-05-29 /pmc/articles/PMC5987168/ /pubmed/29896083 http://dx.doi.org/10.3389/fnins.2018.00357 Text en Copyright © 2018 Gao, Li, Rui, Ni, Liu, Jiang, Tao, Gao and Dang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Gao, Fan
Li, Di
Rui, Qin
Ni, Haibo
Liu, Huixiang
Jiang, Feng
Tao, Li
Gao, Rong
Dang, Baoqi
Annexin A7 Levels Increase in Rats With Traumatic Brain Injury and Promote Secondary Brain Injury
title Annexin A7 Levels Increase in Rats With Traumatic Brain Injury and Promote Secondary Brain Injury
title_full Annexin A7 Levels Increase in Rats With Traumatic Brain Injury and Promote Secondary Brain Injury
title_fullStr Annexin A7 Levels Increase in Rats With Traumatic Brain Injury and Promote Secondary Brain Injury
title_full_unstemmed Annexin A7 Levels Increase in Rats With Traumatic Brain Injury and Promote Secondary Brain Injury
title_short Annexin A7 Levels Increase in Rats With Traumatic Brain Injury and Promote Secondary Brain Injury
title_sort annexin a7 levels increase in rats with traumatic brain injury and promote secondary brain injury
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987168/
https://www.ncbi.nlm.nih.gov/pubmed/29896083
http://dx.doi.org/10.3389/fnins.2018.00357
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