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New insights about the regulation of Nidovirus subgenomic mRNA synthesis
The members of the Order Nidovirales share a similar genome organization with two overlapping nonstructural polyproteins encoded in the 5′ two-thirds and the structural proteins encoded in the 3′ third. They also express their 3′ region proteins from a nested set of 3′ co-terminal subgenomic messeng...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987246/ https://www.ncbi.nlm.nih.gov/pubmed/29475599 http://dx.doi.org/10.1016/j.virol.2018.01.026 |
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author | Di, Han McIntyre, Ayisha A. Brinton, Margo A. |
author_facet | Di, Han McIntyre, Ayisha A. Brinton, Margo A. |
author_sort | Di, Han |
collection | PubMed |
description | The members of the Order Nidovirales share a similar genome organization with two overlapping nonstructural polyproteins encoded in the 5′ two-thirds and the structural proteins encoded in the 3′ third. They also express their 3′ region proteins from a nested set of 3′ co-terminal subgenomic messenger RNAs (sg mRNAs). Some but not all of the Nidovirus sg mRNAs also have a common 5′ leader sequence that is acquired by a discontinuous RNA synthesis mechanism regulated by multiple 3′ body transcription regulating sequences (TRSs) and the 5′ leader TRS. Initial studies detected a single major body TRS for each 3′ sg mRNA with a few alternative functional TRSs reported. The recent application of advanced techniques, such as next generation sequencing and ribosomal profiling, in studies of arteriviruses and coronaviruses has revealed an expanded sg mRNA transcriptome and coding capacity. |
format | Online Article Text |
id | pubmed-5987246 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59872462019-04-01 New insights about the regulation of Nidovirus subgenomic mRNA synthesis Di, Han McIntyre, Ayisha A. Brinton, Margo A. Virology Article The members of the Order Nidovirales share a similar genome organization with two overlapping nonstructural polyproteins encoded in the 5′ two-thirds and the structural proteins encoded in the 3′ third. They also express their 3′ region proteins from a nested set of 3′ co-terminal subgenomic messenger RNAs (sg mRNAs). Some but not all of the Nidovirus sg mRNAs also have a common 5′ leader sequence that is acquired by a discontinuous RNA synthesis mechanism regulated by multiple 3′ body transcription regulating sequences (TRSs) and the 5′ leader TRS. Initial studies detected a single major body TRS for each 3′ sg mRNA with a few alternative functional TRSs reported. The recent application of advanced techniques, such as next generation sequencing and ribosomal profiling, in studies of arteriviruses and coronaviruses has revealed an expanded sg mRNA transcriptome and coding capacity. Elsevier Inc. 2018-04 2018-02-21 /pmc/articles/PMC5987246/ /pubmed/29475599 http://dx.doi.org/10.1016/j.virol.2018.01.026 Text en © 2018 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Di, Han McIntyre, Ayisha A. Brinton, Margo A. New insights about the regulation of Nidovirus subgenomic mRNA synthesis |
title | New insights about the regulation of Nidovirus subgenomic mRNA synthesis |
title_full | New insights about the regulation of Nidovirus subgenomic mRNA synthesis |
title_fullStr | New insights about the regulation of Nidovirus subgenomic mRNA synthesis |
title_full_unstemmed | New insights about the regulation of Nidovirus subgenomic mRNA synthesis |
title_short | New insights about the regulation of Nidovirus subgenomic mRNA synthesis |
title_sort | new insights about the regulation of nidovirus subgenomic mrna synthesis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987246/ https://www.ncbi.nlm.nih.gov/pubmed/29475599 http://dx.doi.org/10.1016/j.virol.2018.01.026 |
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