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Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression

Hepatocellular carcinoma (HCC), which accounts for 85–90% of primary liver cancer, is the fifth most common malignant tumor and the third leading cause of cancer-related deaths worldwide, but the pathological mechanism of HCC is still not fully elucidated. miRNAs are evolutionarily endogenous small...

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Detalles Bibliográficos
Autores principales: Chen, Erbao, Xu, Xiaojing, Liu, Ruiqi, Liu, Tianshu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987324/
https://www.ncbi.nlm.nih.gov/pubmed/29951542
http://dx.doi.org/10.1155/2018/6784607
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author Chen, Erbao
Xu, Xiaojing
Liu, Ruiqi
Liu, Tianshu
author_facet Chen, Erbao
Xu, Xiaojing
Liu, Ruiqi
Liu, Tianshu
author_sort Chen, Erbao
collection PubMed
description Hepatocellular carcinoma (HCC), which accounts for 85–90% of primary liver cancer, is the fifth most common malignant tumor and the third leading cause of cancer-related deaths worldwide, but the pathological mechanism of HCC is still not fully elucidated. miRNAs are evolutionarily endogenous small noncoding RNAs that negatively regulate gene expression via posttranscriptional inhibition or target mRNA degradation in several diseases, especially human cancer. Therefore, discovering the roles of miRNAs is appealing to scientific researchers. Emerging evidence has shown that the aberrant expressions of numerous miRNAs are involved in many HCC biological processes. In hepatocarcinogenesis, miRNAs with dysregulated expression can exert their function as oncogenes or tumor suppressors depending on their cellular target during the cell cycle, and in tumor development, differentiation, apoptosis, angiogenesis, metastasis, and progression of the tumor microenvironment. In this review, we summarize current findings on miRNAs and assess their functions to explore the molecular mechanisms of tumor progression in HCC.
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spelling pubmed-59873242018-06-27 Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression Chen, Erbao Xu, Xiaojing Liu, Ruiqi Liu, Tianshu Biomed Res Int Review Article Hepatocellular carcinoma (HCC), which accounts for 85–90% of primary liver cancer, is the fifth most common malignant tumor and the third leading cause of cancer-related deaths worldwide, but the pathological mechanism of HCC is still not fully elucidated. miRNAs are evolutionarily endogenous small noncoding RNAs that negatively regulate gene expression via posttranscriptional inhibition or target mRNA degradation in several diseases, especially human cancer. Therefore, discovering the roles of miRNAs is appealing to scientific researchers. Emerging evidence has shown that the aberrant expressions of numerous miRNAs are involved in many HCC biological processes. In hepatocarcinogenesis, miRNAs with dysregulated expression can exert their function as oncogenes or tumor suppressors depending on their cellular target during the cell cycle, and in tumor development, differentiation, apoptosis, angiogenesis, metastasis, and progression of the tumor microenvironment. In this review, we summarize current findings on miRNAs and assess their functions to explore the molecular mechanisms of tumor progression in HCC. Hindawi 2018-05-22 /pmc/articles/PMC5987324/ /pubmed/29951542 http://dx.doi.org/10.1155/2018/6784607 Text en Copyright © 2018 Erbao Chen et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chen, Erbao
Xu, Xiaojing
Liu, Ruiqi
Liu, Tianshu
Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression
title Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression
title_full Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression
title_fullStr Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression
title_full_unstemmed Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression
title_short Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression
title_sort small but heavy role: micrornas in hepatocellular carcinoma progression
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987324/
https://www.ncbi.nlm.nih.gov/pubmed/29951542
http://dx.doi.org/10.1155/2018/6784607
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