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Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression
Hepatocellular carcinoma (HCC), which accounts for 85–90% of primary liver cancer, is the fifth most common malignant tumor and the third leading cause of cancer-related deaths worldwide, but the pathological mechanism of HCC is still not fully elucidated. miRNAs are evolutionarily endogenous small...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987324/ https://www.ncbi.nlm.nih.gov/pubmed/29951542 http://dx.doi.org/10.1155/2018/6784607 |
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author | Chen, Erbao Xu, Xiaojing Liu, Ruiqi Liu, Tianshu |
author_facet | Chen, Erbao Xu, Xiaojing Liu, Ruiqi Liu, Tianshu |
author_sort | Chen, Erbao |
collection | PubMed |
description | Hepatocellular carcinoma (HCC), which accounts for 85–90% of primary liver cancer, is the fifth most common malignant tumor and the third leading cause of cancer-related deaths worldwide, but the pathological mechanism of HCC is still not fully elucidated. miRNAs are evolutionarily endogenous small noncoding RNAs that negatively regulate gene expression via posttranscriptional inhibition or target mRNA degradation in several diseases, especially human cancer. Therefore, discovering the roles of miRNAs is appealing to scientific researchers. Emerging evidence has shown that the aberrant expressions of numerous miRNAs are involved in many HCC biological processes. In hepatocarcinogenesis, miRNAs with dysregulated expression can exert their function as oncogenes or tumor suppressors depending on their cellular target during the cell cycle, and in tumor development, differentiation, apoptosis, angiogenesis, metastasis, and progression of the tumor microenvironment. In this review, we summarize current findings on miRNAs and assess their functions to explore the molecular mechanisms of tumor progression in HCC. |
format | Online Article Text |
id | pubmed-5987324 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-59873242018-06-27 Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression Chen, Erbao Xu, Xiaojing Liu, Ruiqi Liu, Tianshu Biomed Res Int Review Article Hepatocellular carcinoma (HCC), which accounts for 85–90% of primary liver cancer, is the fifth most common malignant tumor and the third leading cause of cancer-related deaths worldwide, but the pathological mechanism of HCC is still not fully elucidated. miRNAs are evolutionarily endogenous small noncoding RNAs that negatively regulate gene expression via posttranscriptional inhibition or target mRNA degradation in several diseases, especially human cancer. Therefore, discovering the roles of miRNAs is appealing to scientific researchers. Emerging evidence has shown that the aberrant expressions of numerous miRNAs are involved in many HCC biological processes. In hepatocarcinogenesis, miRNAs with dysregulated expression can exert their function as oncogenes or tumor suppressors depending on their cellular target during the cell cycle, and in tumor development, differentiation, apoptosis, angiogenesis, metastasis, and progression of the tumor microenvironment. In this review, we summarize current findings on miRNAs and assess their functions to explore the molecular mechanisms of tumor progression in HCC. Hindawi 2018-05-22 /pmc/articles/PMC5987324/ /pubmed/29951542 http://dx.doi.org/10.1155/2018/6784607 Text en Copyright © 2018 Erbao Chen et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Chen, Erbao Xu, Xiaojing Liu, Ruiqi Liu, Tianshu Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression |
title | Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression |
title_full | Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression |
title_fullStr | Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression |
title_full_unstemmed | Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression |
title_short | Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression |
title_sort | small but heavy role: micrornas in hepatocellular carcinoma progression |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987324/ https://www.ncbi.nlm.nih.gov/pubmed/29951542 http://dx.doi.org/10.1155/2018/6784607 |
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