Cargando…

Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer

Revealing the gene regulation networks governing cancer initiation and development is necessary while it remains uncompleted. In recent years, enhancers have been reported to be widely transcribed, resulting in the generation of enhancer RNAs (eRNAs). Previous studies have reported that eRNAs are a...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Yuhan, Ding, Mengting, Gao, Qunjun, He, Anbang, Liu, Yuchen, Mei, Hongbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987348/
https://www.ncbi.nlm.nih.gov/pubmed/29951530
http://dx.doi.org/10.1155/2018/2405351
_version_ 1783329094834847744
author Liu, Yuhan
Ding, Mengting
Gao, Qunjun
He, Anbang
Liu, Yuchen
Mei, Hongbing
author_facet Liu, Yuhan
Ding, Mengting
Gao, Qunjun
He, Anbang
Liu, Yuchen
Mei, Hongbing
author_sort Liu, Yuhan
collection PubMed
description Revealing the gene regulation networks governing cancer initiation and development is necessary while it remains uncompleted. In recent years, enhancers have been reported to be widely transcribed, resulting in the generation of enhancer RNAs (eRNAs). Previous studies have reported that eRNAs are a subclass of long noncoding RNAs (lncRNAs), which play a critical role in gene regulation and cancer development. These eRNAs can promote enhancer-promoter (E-P) looping formation by binding to other protein factors or propel expression of downstream protein-coding gene. In this review, we have focused on the characteristics of eRNAs and illustrated the biological function and potential mechanism of eRNAs in regulating gene expression and cancer development.
format Online
Article
Text
id pubmed-5987348
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-59873482018-06-27 Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer Liu, Yuhan Ding, Mengting Gao, Qunjun He, Anbang Liu, Yuchen Mei, Hongbing Biomed Res Int Review Article Revealing the gene regulation networks governing cancer initiation and development is necessary while it remains uncompleted. In recent years, enhancers have been reported to be widely transcribed, resulting in the generation of enhancer RNAs (eRNAs). Previous studies have reported that eRNAs are a subclass of long noncoding RNAs (lncRNAs), which play a critical role in gene regulation and cancer development. These eRNAs can promote enhancer-promoter (E-P) looping formation by binding to other protein factors or propel expression of downstream protein-coding gene. In this review, we have focused on the characteristics of eRNAs and illustrated the biological function and potential mechanism of eRNAs in regulating gene expression and cancer development. Hindawi 2018-05-22 /pmc/articles/PMC5987348/ /pubmed/29951530 http://dx.doi.org/10.1155/2018/2405351 Text en Copyright © 2018 Yuhan Liu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Liu, Yuhan
Ding, Mengting
Gao, Qunjun
He, Anbang
Liu, Yuchen
Mei, Hongbing
Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer
title Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer
title_full Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer
title_fullStr Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer
title_full_unstemmed Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer
title_short Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer
title_sort current advances on the important roles of enhancer rnas in gene regulation and cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987348/
https://www.ncbi.nlm.nih.gov/pubmed/29951530
http://dx.doi.org/10.1155/2018/2405351
work_keys_str_mv AT liuyuhan currentadvancesontheimportantrolesofenhancerrnasingeneregulationandcancer
AT dingmengting currentadvancesontheimportantrolesofenhancerrnasingeneregulationandcancer
AT gaoqunjun currentadvancesontheimportantrolesofenhancerrnasingeneregulationandcancer
AT heanbang currentadvancesontheimportantrolesofenhancerrnasingeneregulationandcancer
AT liuyuchen currentadvancesontheimportantrolesofenhancerrnasingeneregulationandcancer
AT meihongbing currentadvancesontheimportantrolesofenhancerrnasingeneregulationandcancer