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Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer
Revealing the gene regulation networks governing cancer initiation and development is necessary while it remains uncompleted. In recent years, enhancers have been reported to be widely transcribed, resulting in the generation of enhancer RNAs (eRNAs). Previous studies have reported that eRNAs are a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987348/ https://www.ncbi.nlm.nih.gov/pubmed/29951530 http://dx.doi.org/10.1155/2018/2405351 |
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author | Liu, Yuhan Ding, Mengting Gao, Qunjun He, Anbang Liu, Yuchen Mei, Hongbing |
author_facet | Liu, Yuhan Ding, Mengting Gao, Qunjun He, Anbang Liu, Yuchen Mei, Hongbing |
author_sort | Liu, Yuhan |
collection | PubMed |
description | Revealing the gene regulation networks governing cancer initiation and development is necessary while it remains uncompleted. In recent years, enhancers have been reported to be widely transcribed, resulting in the generation of enhancer RNAs (eRNAs). Previous studies have reported that eRNAs are a subclass of long noncoding RNAs (lncRNAs), which play a critical role in gene regulation and cancer development. These eRNAs can promote enhancer-promoter (E-P) looping formation by binding to other protein factors or propel expression of downstream protein-coding gene. In this review, we have focused on the characteristics of eRNAs and illustrated the biological function and potential mechanism of eRNAs in regulating gene expression and cancer development. |
format | Online Article Text |
id | pubmed-5987348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-59873482018-06-27 Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer Liu, Yuhan Ding, Mengting Gao, Qunjun He, Anbang Liu, Yuchen Mei, Hongbing Biomed Res Int Review Article Revealing the gene regulation networks governing cancer initiation and development is necessary while it remains uncompleted. In recent years, enhancers have been reported to be widely transcribed, resulting in the generation of enhancer RNAs (eRNAs). Previous studies have reported that eRNAs are a subclass of long noncoding RNAs (lncRNAs), which play a critical role in gene regulation and cancer development. These eRNAs can promote enhancer-promoter (E-P) looping formation by binding to other protein factors or propel expression of downstream protein-coding gene. In this review, we have focused on the characteristics of eRNAs and illustrated the biological function and potential mechanism of eRNAs in regulating gene expression and cancer development. Hindawi 2018-05-22 /pmc/articles/PMC5987348/ /pubmed/29951530 http://dx.doi.org/10.1155/2018/2405351 Text en Copyright © 2018 Yuhan Liu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Liu, Yuhan Ding, Mengting Gao, Qunjun He, Anbang Liu, Yuchen Mei, Hongbing Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer |
title | Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer |
title_full | Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer |
title_fullStr | Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer |
title_full_unstemmed | Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer |
title_short | Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer |
title_sort | current advances on the important roles of enhancer rnas in gene regulation and cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987348/ https://www.ncbi.nlm.nih.gov/pubmed/29951530 http://dx.doi.org/10.1155/2018/2405351 |
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