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Body mass index and lung cancer risk in never smokers: a meta-analysis
BACKGROUND: Obesity is found to increase the risk of most cancer types, but reduce lung cancer risk in many studies. However, the association between obesity and lung cancer is still controversial, mainly owing to the confounding effect of smoking. METHODS: Eligible studies were identified from elec...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987408/ https://www.ncbi.nlm.nih.gov/pubmed/29866064 http://dx.doi.org/10.1186/s12885-018-4543-y |
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author | Zhu, Hongjun Zhang, Shuanglin |
author_facet | Zhu, Hongjun Zhang, Shuanglin |
author_sort | Zhu, Hongjun |
collection | PubMed |
description | BACKGROUND: Obesity is found to increase the risk of most cancer types, but reduce lung cancer risk in many studies. However, the association between obesity and lung cancer is still controversial, mainly owing to the confounding effect of smoking. METHODS: Eligible studies were identified from electric databases to July 1, 2017. Relevant data were extracted and pooled using random-effects models; dose-response and subgroup analyses were also performed. RESULTS: Twenty-nine studies with more than 10,000 lung cancer cases in15 million never smokers were included. Compared with normal weight, the summary relative risk (RR) was 0.77(95% confidence interval [CI]: 0.68–0.88, P < 0.01) for excess body weight (body mass index [BMI] ≥ 25 kg/m(2)). An inverse linear dose-response relationship was observed between BMI and lung cancer risk in never smokers, with an RR of 0.89(95% CI: 0.84–0.95, P < 0.01) per 5 kg/m(2) increment in BMI. The results remained stable in most subgroup analyses. However, when stratified by sex, a significant inverse association existed in women but not in men. Similar results were found in analyses for other categories of BMI. CONCLUSION: Our results indicate that higher BMI is associated with lower lung cancer risk in never smokers. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12885-018-4543-y) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5987408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-59874082018-07-10 Body mass index and lung cancer risk in never smokers: a meta-analysis Zhu, Hongjun Zhang, Shuanglin BMC Cancer Research Article BACKGROUND: Obesity is found to increase the risk of most cancer types, but reduce lung cancer risk in many studies. However, the association between obesity and lung cancer is still controversial, mainly owing to the confounding effect of smoking. METHODS: Eligible studies were identified from electric databases to July 1, 2017. Relevant data were extracted and pooled using random-effects models; dose-response and subgroup analyses were also performed. RESULTS: Twenty-nine studies with more than 10,000 lung cancer cases in15 million never smokers were included. Compared with normal weight, the summary relative risk (RR) was 0.77(95% confidence interval [CI]: 0.68–0.88, P < 0.01) for excess body weight (body mass index [BMI] ≥ 25 kg/m(2)). An inverse linear dose-response relationship was observed between BMI and lung cancer risk in never smokers, with an RR of 0.89(95% CI: 0.84–0.95, P < 0.01) per 5 kg/m(2) increment in BMI. The results remained stable in most subgroup analyses. However, when stratified by sex, a significant inverse association existed in women but not in men. Similar results were found in analyses for other categories of BMI. CONCLUSION: Our results indicate that higher BMI is associated with lower lung cancer risk in never smokers. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12885-018-4543-y) contains supplementary material, which is available to authorized users. BioMed Central 2018-06-05 /pmc/articles/PMC5987408/ /pubmed/29866064 http://dx.doi.org/10.1186/s12885-018-4543-y Text en © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Zhu, Hongjun Zhang, Shuanglin Body mass index and lung cancer risk in never smokers: a meta-analysis |
title | Body mass index and lung cancer risk in never smokers: a meta-analysis |
title_full | Body mass index and lung cancer risk in never smokers: a meta-analysis |
title_fullStr | Body mass index and lung cancer risk in never smokers: a meta-analysis |
title_full_unstemmed | Body mass index and lung cancer risk in never smokers: a meta-analysis |
title_short | Body mass index and lung cancer risk in never smokers: a meta-analysis |
title_sort | body mass index and lung cancer risk in never smokers: a meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987408/ https://www.ncbi.nlm.nih.gov/pubmed/29866064 http://dx.doi.org/10.1186/s12885-018-4543-y |
work_keys_str_mv | AT zhuhongjun bodymassindexandlungcancerriskinneversmokersametaanalysis AT zhangshuanglin bodymassindexandlungcancerriskinneversmokersametaanalysis |