Cargando…

Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke

BACKGROUND: Subtle adjustment of the activation status of CNS resident microglia and peripheral macrophages, to promote their neuroprotective and neuroregenerative functions, may facilitate research towards curing neurodegenerative disorders. In the present study, we investigated whether targeted in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hamzei Taj, Somayyeh, Le Blon, Debbie, Hoornaert, Chloé, Daans, Jasmijn, Quarta, Alessandra, Praet, Jelle, Van der Linden, Annemie, Ponsaerts, Peter, Hoehn, Mathias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987479/ https://www.ncbi.nlm.nih.gov/pubmed/29866203 http://dx.doi.org/10.1186/s12974-018-1212-7

Ejemplares similares

Tackling the physiological barriers for successful mesenchymal stem cell transplantation into the central nervous system
por: De Vocht, Nathalie, et al.
Publicado: (2013)

Concise Review: Innate and Adaptive Immune Recognition of Allogeneic and Xenogeneic Cell Transplants in the Central Nervous System
por: Hoornaert, Chloé J., et al.
Publicado: (2017)

Spatiotemporal evolution of early innate immune responses triggered by neural stem cell grafting
por: Reekmans, Kristien, et al.
Publicado: (2012)

Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model
por: Le Blon, Debbie, et al.
Publicado: (2016)

Cuprizone-induced demyelination and demyelination-associated inflammation result in different proton magnetic resonance metabolite spectra
por: Praet, Jelle, et al.
Publicado: (2015)

Dynamic Modulation of Microglia/Macrophage Polarization by miR-124 after Focal Cerebral Ischemia
por: Hamzei Taj, Somayyeh, et al.
Publicado: (2016)

Individual in vivo Profiles of Microglia Polarization After Stroke, Represented by the Genes iNOS and Ym1
por: Collmann, Franziska M., et al.
Publicado: (2019)

Cell-Based Delivery of Interleukin-13 Directs Alternative Activation of Macrophages Resulting in Improved Functional Outcome after Spinal Cord Injury
por: Dooley, Dearbhaile, et al.
Publicado: (2016)

Increased soluble amyloid-beta causes early aberrant brain network hypersynchronisation in a mature-onset mouse model of amyloidosis
por: Ben-Nejma, Inès R. H., et al.
Publicado: (2019)

Monitoring Neuronal Network Disturbances of Brain Diseases: A Preclinical MRI Approach in the Rodent Brain
por: Van der Linden, Annemie, et al.
Publicado: (2022)

Reporter gene-expressing bone marrow-derived stromal cells are immune-tolerated following implantation in the central nervous system of syngeneic immunocompetent mice
por: Bergwerf, Irene, et al.
Publicado: (2009)

In Vivo Fate Imaging of Intracerebral Stem Cell Grafts in Mouse Brain
por: Tennstaedt, Annette, et al.
Publicado: (2015)

Mechanism and Regulation of Microglia Polarization in Intracerebral Hemorrhage
por: Guo, Yuting, et al.
Publicado: (2022)

Microglia Phenotype and Intracerebral Hemorrhage: A Balance of Yin and Yang
por: Bi, Rentang, et al.
Publicado: (2021)

Erythrophagocytosis by Microglia/Macrophage in Intracerebral Hemorrhage: From Mechanisms to Translation
por: Liu, Jiaxin, et al.
Publicado: (2022)

Effects and mechanism of myeloperoxidase on microglia in the early stage of intracerebral hemorrhage
por: Zuo, Wei, et al.
Publicado: (2022)

Plasmid-based genetic modification of human bone marrow-derived stromal cells: analysis of cell survival and transgene expression after transplantation in rat spinal cord
por: Ronsyn, Mark W, et al.
Publicado: (2007)

Magnetization transfer contrast imaging detects early white matter changes in the APP/PS1 amyloidosis mouse model
por: Praet, Jelle, et al.
Publicado: (2016)

Eupatilin inhibits microglia activation and attenuates brain injury in intracerebral hemorrhage
por: Qiao, Hai-Bo, et al.
Publicado: (2018)

Neuroinflammation of microglia polarization in intracerebral hemorrhage and its potential targets for intervention
por: Yang, Guoqiang, et al.
Publicado: (2022)

Injury-Dependent Retention of Intraportally Administered Mesenchymal Stromal Cells Following Partial Hepatectomy of Steatotic Liver Does Not Lead to Improved Liver Recovery
por: Boeykens, Nele, et al.
Publicado: (2013)

The effect of a hydro-alcoholic extract of olive fruit on reproductive argons in male sprague-dawley rat
por: Najafizadeh, Parvaneh, et al.
Publicado: (2013)

Intracerebral Proinflammatory Cytokine Increase in Surgically Evacuated Intracerebral Hemorrhage: A Microdialysis Study
por: Tobieson, Lovisa, et al.
Publicado: (2021)

Microglia–Neuron Crosstalk in Obesity: Melodious Interaction or Kiss of Death?
por: Léon, Stéphane, et al.
Publicado: (2021)

High Morphologic Plasticity of Microglia/Macrophages Following Experimental Intracerebral Hemorrhage in Rats
por: Yang, Shu-Sheng, et al.
Publicado: (2016)

Imaging Reporter Strategy to Monitor Gene Activation of Microglia Polarisation States under Stimulation
por: Collmann, Franziska M., et al.
Publicado: (2018)

Resting State fMRI Reveals Diminished Functional Connectivity in a Mouse Model of Amyloidosis
por: Shah, Disha, et al.
Publicado: (2013)

Correction: Resting State fMRI Reveals Diminished Functional Connectivity in a Mouse Model of Amyloidosis
por: Shah, Disha, et al.
Publicado: (2014)

Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA
por: Derdelinckx, Judith, et al.
Publicado: (2019)

Immunomodulatory Effect of Microglia-Released Cytokines in Gliomas
por: Lanza, Marika, et al.
Publicado: (2021)

Differential Cytokine-Induced Responses of Polarized Microglia
por: Chauhan, Priyanka, et al.
Publicado: (2021)

Altered dynamics of glymphatic flow in a mature-onset Tet-off APP mouse model of amyloidosis
por: Ben-Nejma, Inès R. H., et al.
Publicado: (2023)

NOD1/RIP2 signalling enhances the microglia-driven inflammatory response and undergoes crosstalk with inflammatory cytokines to exacerbate brain damage following intracerebral haemorrhage in mice
por: Wang, Miao, et al.
Publicado: (2020)

Interleukin-4 Ameliorates the Functional Recovery of Intracerebral Hemorrhage Through the Alternative Activation of Microglia/Macrophage
por: Yang, Jianjing, et al.
Publicado: (2016)

Microglia: A Double-Edged Sword in Intracerebral Hemorrhage From Basic Mechanisms to Clinical Research
por: Liu, Jiachen, et al.
Publicado: (2021)

Temporal dynamics of microglia-astrocyte interaction in neuroprotective glial scar formation after intracerebral hemorrhage
por: Zheng, Jingwei, et al.
Publicado: (2023)

Multimodal in vivo imaging reveals limited allograft survival, intrapulmonary cell trapping and minimal evidence for ischemia-directed BMSC homing
por: Everaert, Bert R, et al.
Publicado: (2012)

Expression of Translocator Protein and [18F]-GE180 Ligand Uptake in Multiple Sclerosis Animal Models
por: Nack, Anne, et al.
Publicado: (2019)

Microglia are both a source and target of extracellular cyclophilin A
por: Flora, Gurkiran Kaur, et al.
Publicado: (2019)

MicroRNA367 negatively regulates the inflammatory response of microglia by targeting IRAK4 in intracerebral hemorrhage
por: Yuan, Bangqing, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_gahrrrcjg5frvfblr9u3d2bhbk