Cargando…

Active and inactive β1 integrins segregate into distinct nanoclusters in focal adhesions

Integrins are the core constituents of cell–matrix adhesion complexes such as focal adhesions (FAs) and play key roles in physiology and disease. Integrins fluctuate between active and inactive conformations, yet whether the activity state influences the spatial organization of integrins within FAs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Spiess, Matthias, Hernandez-Varas, Pablo, Oddone, Anna, Olofsson, Helene, Blom, Hans, Waithe, Dominic, Lock, John G., Lakadamyali, Melike, Strömblad, Staffan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987715/ https://www.ncbi.nlm.nih.gov/pubmed/29632027 http://dx.doi.org/10.1083/jcb.201707075

Ejemplares similares

Integrin-mediated Cell Attachment Induces a PAK4-dependent Feedback Loop Regulating Cell Adhesion through Modified Integrin αvβ5 Clustering and Turnover
por: Li, Zhilun, et al.
Publicado: (2010)

A plastic relationship between vinculin-mediated tension and adhesion complex area defines adhesion size and lifetime
por: Hernández-Varas, Pablo, et al.
Publicado: (2015)

Identification of the PAK4 interactome reveals PAK4 phosphorylation of N-WASP and promotion of Arp2/3-dependent actin polymerization
por: Zhao, Miao, et al.
Publicado: (2017)

Focal adhesions are sites of integrin extension
por: Askari, Janet A., et al.
Publicado: (2010)

Changes in membrane sphingolipid composition modulate dynamics and adhesion of integrin nanoclusters
por: Eich, Christina, et al.
Publicado: (2016)

Use of an Immobilized Monoclonal Antibody to Examine Integrin α5β1 Signaling Independent of Cell Spreading
por: Bao, Wenjie, et al.
Publicado: (2002)

Clathrin-containing adhesion complexes
por: Lock, John G., et al.
Publicado: (2019)

Integrin αv-mediated inactivation of p53 controls a MEK1-dependent melanoma cell survival pathway in three-dimensional collagen
por: Bao, Wenjie, et al.
Publicado: (2004)

Integrins outside focal adhesions transmit tensions during stable cell adhesion
por: Wang, Yongliang, et al.
Publicado: (2016)

Cell Cycle Regulation by Integrin-Mediated Adhesion
por: Kamranvar, Siamak A., et al.
Publicado: (2022)

Integrin αvβ3 Requirement for Sustained Mitogen-activated Protein Kinase Activity during Angiogenesis
por: Eliceiri, Brian P., et al.
Publicado: (1998)

Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cells
por: Ezratty, Ellen J., et al.
Publicado: (2009)

Disentangling Membrane Dynamics and Cell Migration; Differential Influences of F-actin and Cell-Matrix Adhesions
por: Kowalewski, Jacob M., et al.
Publicado: (2015)

p21-activated kinase 4 interacts with integrin αvβ5 and regulates αvβ5-mediated cell migration
por: Zhang, Hongquan, et al.
Publicado: (2002)

KIF13A‐regulated RhoB plasma membrane localization governs membrane blebbing and blebby amoeboid cell migration
por: Gong, Xiaowei, et al.
Publicado: (2018)

Integrin-specific signaling pathways controlling focal adhesion formation and cell migration
por: Mostafavi-Pour, Zohreh, et al.
Publicado: (2003)

Canonical Wnt signaling induces focal adhesion and Integrin beta-1 endocytosis
por: Tejeda-Muñoz, Nydia, et al.
Publicado: (2022)

Integrin molecular tension required for focal adhesion maturation and YAP nuclear translocation
por: Chang Chien, Cheng-Yu, et al.
Publicado: (2022)

A New Focal Adhesion Protein That Interacts with Integrin-Linked Kinase and Regulates Cell Adhesion and Spreading
por: Tu, Yizeng, et al.
Publicado: (2001)

Contribution of integrin adhesion to cytokinetic abscission and genomic integrity
por: Rani, Bhavna, et al.
Publicado: (2022)

Spatiotemporal segregation of endothelial cell integrin and nonintegrin extracellular matrix-binding proteins during adhesion events
Publicado: (1990)

Quantitative Changes in Integrin and Focal Adhesion Signaling Regulate Myoblast Cell Cycle Withdrawal
por: Sastry, Sarita K., et al.
Publicado: (1999)

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains
Publicado: (1995)

Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions
por: Orré, Thomas, et al.
Publicado: (2021)

Distinct Recycling of Active and Inactive β1 Integrins
por: Arjonen, Antti, et al.
Publicado: (2012)

An analysis toolbox to explore mesenchymal migration heterogeneity reveals adaptive switching between distinct modes
por: Shafqat-Abbasi, Hamdah, et al.
Publicado: (2016)

SUPERRESOLUTION IMAGING OF CHROMATIN IN HEALTH AND DISEASE
por: Lakadamyali, Melike
Publicado: (2022)

Focal Adhesion Kinase Mediates the Integrin Signaling Requirement for Growth Factor Activation of Map Kinase
por: Renshaw, Mark W., et al.
Publicado: (1999)

Integrin-Specific Control of Focal Adhesion Kinase and RhoA Regulates Membrane Protrusion and Invasion
por: Costa, Patricia, et al.
Publicado: (2013)

The focal adhesion protein Integrin-Linked Kinase (ILK) as an important player in breast cancer pathogenesis
por: Tsirtsaki, Katerina, et al.
Publicado: (2020)

Extracellular matrix sensing via modulation of orientational order of integrins and F-actin in focal adhesions
por: Grudtsyna, Valeriia, et al.
Publicado: (2023)

Integrin-Mediated Adhesion Promotes Centrosome Separation in Early Mitosis
por: Kamranvar, Siamak A., et al.
Publicado: (2022)

Integrins on eggs: focal adhesion kinase is activated at fertilization, forms a complex with integrins, and is necessary for cortex formation and cell cycle initiation
por: Chan, D., et al.
Publicado: (2013)

Evidence That β3 Integrin-Induced Rac Activation Involves the Calpain-Dependent Formation of Integrin Clusters That Are Distinct from the Focal Complexes and Focal Adhesions That Form as Rac and Rhoa Become Active
por: Bialkowska, Katarzyna, et al.
Publicado: (2000)

Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions
Publicado: (1993)

Integrin α5/fibronectin1 and focal adhesion kinase are required for lens fiber morphogenesis in zebrafish
por: Hayes, Julie M., et al.
Publicado: (2012)

Apigenin Attenuates Melanoma Cell Migration by Inducing Anoikis through Integrin and Focal Adhesion Kinase Inhibition
por: Hasnat, Md. Abul, et al.
Publicado: (2015)

Integrin α2β1 in nonactivated conformation can induce focal adhesion kinase signaling
por: Salmela, Maria, et al.
Publicado: (2017)

An IFT20 mechanotrafficking axis is required for integrin recycling, focal adhesion dynamics, and polarized cell migration
por: Su, Steven, et al.
Publicado: (2020)

Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration
por: Wu, Jui-Chung, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_abkn9jfbir6al9o9ugo84nucpp