Protein kinase A activation: Something new under the sun?

The role of autophosphorylation of the type II regulatory subunit in activation of protein kinase A (PKA) has been a longstanding question. In this issue, Isensee et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201708053) use antibody tools that selectively recognize phosphorylated RII and t...

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Detalles Bibliográficos
Autores principales: Smith, F. Donelson, Scott, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987730/
https://www.ncbi.nlm.nih.gov/pubmed/29773583
http://dx.doi.org/10.1083/jcb.201805011
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author Smith, F. Donelson
Scott, John D.
author_facet Smith, F. Donelson
Scott, John D.
author_sort Smith, F. Donelson
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description The role of autophosphorylation of the type II regulatory subunit in activation of protein kinase A (PKA) has been a longstanding question. In this issue, Isensee et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201708053) use antibody tools that selectively recognize phosphorylated RII and the catalytic subunit active site to reexamine PKA holoenzyme activation mechanisms in neurons.
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spelling pubmed-59877302018-12-04 Protein kinase A activation: Something new under the sun? Smith, F. Donelson Scott, John D. J Cell Biol Commentaries The role of autophosphorylation of the type II regulatory subunit in activation of protein kinase A (PKA) has been a longstanding question. In this issue, Isensee et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201708053) use antibody tools that selectively recognize phosphorylated RII and the catalytic subunit active site to reexamine PKA holoenzyme activation mechanisms in neurons. Rockefeller University Press 2018-06-04 /pmc/articles/PMC5987730/ /pubmed/29773583 http://dx.doi.org/10.1083/jcb.201805011 Text en © 2018 Smith and Scott http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Smith, F. Donelson
Scott, John D.
Protein kinase A activation: Something new under the sun?
title Protein kinase A activation: Something new under the sun?
title_full Protein kinase A activation: Something new under the sun?
title_fullStr Protein kinase A activation: Something new under the sun?
title_full_unstemmed Protein kinase A activation: Something new under the sun?
title_short Protein kinase A activation: Something new under the sun?
title_sort protein kinase a activation: something new under the sun?
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987730/
https://www.ncbi.nlm.nih.gov/pubmed/29773583
http://dx.doi.org/10.1083/jcb.201805011
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