EB1 traps STIM1 and regulates local store-operated Ca(2+) entry

STIM1 activates store-operated Ca(2+) entry when Ca(2+) in the endoplasmic reticulum (ER) is depleted. In this issue, Chang et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201711151) demonstrate that EB1 traps STIM1 at dynamic contacts between the ER and microtubule plus ends, delaying STIM1...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Qiao-Chu, Wang, Xi, Tang, Tie-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987731/
https://www.ncbi.nlm.nih.gov/pubmed/29764906
http://dx.doi.org/10.1083/jcb.201805037
_version_ 1783329178597195776
author Wang, Qiao-Chu
Wang, Xi
Tang, Tie-Shan
author_facet Wang, Qiao-Chu
Wang, Xi
Tang, Tie-Shan
author_sort Wang, Qiao-Chu
collection PubMed
description STIM1 activates store-operated Ca(2+) entry when Ca(2+) in the endoplasmic reticulum (ER) is depleted. In this issue, Chang et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201711151) demonstrate that EB1 traps STIM1 at dynamic contacts between the ER and microtubule plus ends, delaying STIM1 translocation to ER–plasma membrane junctions and preventing Ca(2+) overload.
format Online
Article
Text
id pubmed-5987731
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-59877312018-12-04 EB1 traps STIM1 and regulates local store-operated Ca(2+) entry Wang, Qiao-Chu Wang, Xi Tang, Tie-Shan J Cell Biol Commentaries STIM1 activates store-operated Ca(2+) entry when Ca(2+) in the endoplasmic reticulum (ER) is depleted. In this issue, Chang et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201711151) demonstrate that EB1 traps STIM1 at dynamic contacts between the ER and microtubule plus ends, delaying STIM1 translocation to ER–plasma membrane junctions and preventing Ca(2+) overload. Rockefeller University Press 2018-06-04 /pmc/articles/PMC5987731/ /pubmed/29764906 http://dx.doi.org/10.1083/jcb.201805037 Text en © 2018 Wang et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Wang, Qiao-Chu
Wang, Xi
Tang, Tie-Shan
EB1 traps STIM1 and regulates local store-operated Ca(2+) entry
title EB1 traps STIM1 and regulates local store-operated Ca(2+) entry
title_full EB1 traps STIM1 and regulates local store-operated Ca(2+) entry
title_fullStr EB1 traps STIM1 and regulates local store-operated Ca(2+) entry
title_full_unstemmed EB1 traps STIM1 and regulates local store-operated Ca(2+) entry
title_short EB1 traps STIM1 and regulates local store-operated Ca(2+) entry
title_sort eb1 traps stim1 and regulates local store-operated ca(2+) entry
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987731/
https://www.ncbi.nlm.nih.gov/pubmed/29764906
http://dx.doi.org/10.1083/jcb.201805037
work_keys_str_mv AT wangqiaochu eb1trapsstim1andregulateslocalstoreoperatedca2entry
AT wangxi eb1trapsstim1andregulateslocalstoreoperatedca2entry
AT tangtieshan eb1trapsstim1andregulateslocalstoreoperatedca2entry

Ejemplares similares