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Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation
Additional sex combs like 1 (ASXL1) is frequently mutated in myeloid malignancies and clonal hematopoiesis of indeterminate potential (CHIP). Although loss of ASXL1 promotes hematopoietic transformation, there is growing evidence that ASXL1 mutations might confer an alteration of function. In this s...
Autores principales: | Nagase, Reina, Inoue, Daichi, Pastore, Alessandro, Fujino, Takeshi, Hou, Hsin-An, Yamasaki, Norimasa, Goyama, Susumu, Saika, Makoto, Kanai, Akinori, Sera, Yasuyuki, Horikawa, Sayuri, Ota, Yasunori, Asada, Shuhei, Hayashi, Yasutaka, Kawabata, Kimihito Cojin, Takeda, Reina, Tien, Hwei-Fang, Honda, Hiroaki, Abdel-Wahab, Omar, Kitamura, Toshio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987913/ https://www.ncbi.nlm.nih.gov/pubmed/29643185 http://dx.doi.org/10.1084/jem.20171151 |
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