Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses

T follicular helper (Tfh) cells are required to develop germinal center (GC) responses and drive immunoglobulin class switch, affinity maturation, and long-term B cell memory. In this study, we characterize a recently developed vaccine platform, nucleoside-modified, purified mRNA encapsulated in lip...

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Detalles Bibliográficos
Autores principales: Pardi, Norbert, Hogan, Michael J., Naradikian, Martin S., Parkhouse, Kaela, Cain, Derek W., Jones, Letitia, Moody, M. Anthony, Verkerke, Hans P., Myles, Arpita, Willis, Elinor, LaBranche, Celia C., Montefiori, David C., Lobby, Jenna L., Saunders, Kevin O., Liao, Hua-Xin, Korber, Bette T., Sutherland, Laura L., Scearce, Richard M., Hraber, Peter T., Tombácz, István, Muramatsu, Hiromi, Ni, Houping, Balikov, Daniel A., Li, Charles, Mui, Barbara L., Tam, Ying K., Krammer, Florian, Karikó, Katalin, Polacino, Patricia, Eisenlohr, Laurence C., Madden, Thomas D., Hope, Michael J., Lewis, Mark G., Lee, Kelly K., Hu, Shiu-Lok, Hensley, Scott E., Cancro, Michael P., Haynes, Barton F., Weissman, Drew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987916/
https://www.ncbi.nlm.nih.gov/pubmed/29739835
http://dx.doi.org/10.1084/jem.20171450

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