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Targeting tumor cell plasticity by combined inhibition of NOTCH and MAPK signaling in colon cancer

In colorectal cancer, signaling pathways driving tumor progression are promising targets for systemic therapy. Besides WNT and MAPK signaling, activation of NOTCH signaling is found in most tumors. Here, we demonstrate that high NOTCH activity marks a distinct colon cancer cell subpopulation with lo...

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Detalles Bibliográficos
Autores principales:	Schmidt, Eva Marina, Lamprecht, Sebastian, Blaj, Cristina, Schaaf, Christian, Krebs, Stefan, Blum, Helmut, Hermeking, Heiko, Jung, Andreas, Kirchner, Thomas, Horst, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987917/ https://www.ncbi.nlm.nih.gov/pubmed/29769248 http://dx.doi.org/10.1084/jem.20171455

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