P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer’s disease model

Astrocytic hyperactivity is an important contributor to neuronal-glial network dysfunction in Alzheimer’s disease (AD). We have previously shown that astrocyte hyperactivity is mediated by signaling through the P2Y1 purinoreceptor (P2Y1R) pathway. Using the APPPS1 mouse model of AD, we here find tha...

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Detalles Bibliográficos
Autores principales: Reichenbach, Nicole, Delekate, Andrea, Breithausen, Björn, Keppler, Kevin, Poll, Stefanie, Schulte, Theresa, Peter, Jan, Plescher, Monika, Hansen, Jan N., Blank, Nelli, Keller, Armin, Fuhrmann, Martin, Henneberger, Christian, Halle, Annett, Petzold, Gabor C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987918/
https://www.ncbi.nlm.nih.gov/pubmed/29724785
http://dx.doi.org/10.1084/jem.20171487

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