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Deciphering lipid structures based on platform-independent decision rule sets
We developed decision rule sets for Lipid Data Analyzer (LDA; http://genome.tugraz.at/lda2), enabling automated and reliable annotation of lipid species and their molecular structures in high-throughput data from chromatography-coupled tandem mass spectrometry. Platform independence was proven in va...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988032/ https://www.ncbi.nlm.nih.gov/pubmed/29058722 http://dx.doi.org/10.1038/nmeth.4470 |
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author | Hartler, Jürgen Triebl, Alexander Ziegl, Andreas Trötzmüller, Martin Rechberger, Gerald N Zeleznik, Oana A Zierler, Kathrin A Torta, Federico Cazenave-Gassiot, Amaury Wenk, Markus R Fauland, Alexander Wheelock, Craig E Armando, Aaron M Quehenberger, Oswald Zhang, Qifeng Wakelam, Michael J O Haemmerle, Guenter Spener, Friedrich Köfeler, Harald C Thallinger, Gerhard G |
author_facet | Hartler, Jürgen Triebl, Alexander Ziegl, Andreas Trötzmüller, Martin Rechberger, Gerald N Zeleznik, Oana A Zierler, Kathrin A Torta, Federico Cazenave-Gassiot, Amaury Wenk, Markus R Fauland, Alexander Wheelock, Craig E Armando, Aaron M Quehenberger, Oswald Zhang, Qifeng Wakelam, Michael J O Haemmerle, Guenter Spener, Friedrich Köfeler, Harald C Thallinger, Gerhard G |
author_sort | Hartler, Jürgen |
collection | PubMed |
description | We developed decision rule sets for Lipid Data Analyzer (LDA; http://genome.tugraz.at/lda2), enabling automated and reliable annotation of lipid species and their molecular structures in high-throughput data from chromatography-coupled tandem mass spectrometry. Platform independence was proven in various mass spectrometric experiments, comprising low- and high-resolution instruments and several collision energies. We propose that this independence and the capability to identify novel lipid molecular species render current state-of-the-art lipid libraries now obsolete. |
format | Online Article Text |
id | pubmed-5988032 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
record_format | MEDLINE/PubMed |
spelling | pubmed-59880322018-06-05 Deciphering lipid structures based on platform-independent decision rule sets Hartler, Jürgen Triebl, Alexander Ziegl, Andreas Trötzmüller, Martin Rechberger, Gerald N Zeleznik, Oana A Zierler, Kathrin A Torta, Federico Cazenave-Gassiot, Amaury Wenk, Markus R Fauland, Alexander Wheelock, Craig E Armando, Aaron M Quehenberger, Oswald Zhang, Qifeng Wakelam, Michael J O Haemmerle, Guenter Spener, Friedrich Köfeler, Harald C Thallinger, Gerhard G Nat Methods Article We developed decision rule sets for Lipid Data Analyzer (LDA; http://genome.tugraz.at/lda2), enabling automated and reliable annotation of lipid species and their molecular structures in high-throughput data from chromatography-coupled tandem mass spectrometry. Platform independence was proven in various mass spectrometric experiments, comprising low- and high-resolution instruments and several collision energies. We propose that this independence and the capability to identify novel lipid molecular species render current state-of-the-art lipid libraries now obsolete. 2017-10-23 2017-12 /pmc/articles/PMC5988032/ /pubmed/29058722 http://dx.doi.org/10.1038/nmeth.4470 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Hartler, Jürgen Triebl, Alexander Ziegl, Andreas Trötzmüller, Martin Rechberger, Gerald N Zeleznik, Oana A Zierler, Kathrin A Torta, Federico Cazenave-Gassiot, Amaury Wenk, Markus R Fauland, Alexander Wheelock, Craig E Armando, Aaron M Quehenberger, Oswald Zhang, Qifeng Wakelam, Michael J O Haemmerle, Guenter Spener, Friedrich Köfeler, Harald C Thallinger, Gerhard G Deciphering lipid structures based on platform-independent decision rule sets |
title | Deciphering lipid structures based on platform-independent decision rule sets |
title_full | Deciphering lipid structures based on platform-independent decision rule sets |
title_fullStr | Deciphering lipid structures based on platform-independent decision rule sets |
title_full_unstemmed | Deciphering lipid structures based on platform-independent decision rule sets |
title_short | Deciphering lipid structures based on platform-independent decision rule sets |
title_sort | deciphering lipid structures based on platform-independent decision rule sets |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988032/ https://www.ncbi.nlm.nih.gov/pubmed/29058722 http://dx.doi.org/10.1038/nmeth.4470 |
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