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Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18

Infection with Burkholderia pseudomallei or B. thailandensis triggers activation of the NLRP3 and NLRC4 inflammasomes leading to release of IL-1β and IL-18 and death of infected macrophages by pyroptosis, respectively. The non-canonical inflammasome composed of caspase-11 is also activated by these...

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Detalles Bibliográficos
Autores principales:	Wang, Jinyong, Sahoo, Manoranjan, Lantier, Louis, Warawa, Jonathan, Cordero, Hector, Deobald, Kelly, Re, Fabio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988316/ https://www.ncbi.nlm.nih.gov/pubmed/29791511 http://dx.doi.org/10.1371/journal.ppat.1007105

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