Vaccine-induced antibodies to herpes simplex virus glycoprotein D epitopes involved in virus entry and cell-to-cell spread correlate with protection against genital disease in guinea pigs

Herpes simplex virus type 2 (HSV-2) glycoprotein D (gD2) subunit antigen is included in many preclinical candidate vaccines. The rationale for including gD2 is to produce antibodies that block crucial gD2 epitopes involved in virus entry and cell-to-cell spread. HSV-2 gD2 was the only antigen in the...

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Detalles Bibliográficos
Autores principales: Hook, Lauren M., Cairns, Tina M., Awasthi, Sita, Brooks, Benjamin D., Ditto, Noah T., Eisenberg, Roselyn J., Cohen, Gary H., Friedman, Harvey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988323/
https://www.ncbi.nlm.nih.gov/pubmed/29791513
http://dx.doi.org/10.1371/journal.ppat.1007095

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