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Introducing the Affinity Binder Knockdown Initiative⿿A public⿿private partnership for validation of affinity reagents

The newly launched Affinity Binder Knockdown Initiative encourages antibody suppliers and users to join this public⿿private partnership, which uses crowdsourcing to collect characterization data on antibodies. Researchers are asked to share validation data from experiments where gene-editing techniq...

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Detalles Bibliográficos
Autores principales: Alm, Tove, Lundberg, Emma, Uhlén, Mathias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988587/
https://www.ncbi.nlm.nih.gov/pubmed/29900101
http://dx.doi.org/10.1016/j.euprot.2016.01.002
Descripción
Sumario:The newly launched Affinity Binder Knockdown Initiative encourages antibody suppliers and users to join this public⿿private partnership, which uses crowdsourcing to collect characterization data on antibodies. Researchers are asked to share validation data from experiments where gene-editing techniques (such as siRNA or CRISPR) have been used to verify antibody binding. The initiative is launched under the aegis of Antibodypedia, a database designed to allow comparisons and scoring of publicly available antibodies towards human protein targets. What is known about an antibody is the foundation of the scoring and ranking system in Antibodypedia.