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Mammalian Sterile20-like Kinases: Signalings and Roles in Central Nervous System
Mammalian Sterile20-like (MST) kinases are located upstream in the mitogen-activated protein kinase pathway, and play an important role in cell proliferation, differentiation, renewal, polarization and migration. Generally, five MST kinases exist in mammalian signal transduction pathways, including...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JKL International LLC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988607/ https://www.ncbi.nlm.nih.gov/pubmed/29896440 http://dx.doi.org/10.14336/AD.2017.0702 |
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author | Chen, Sheng Fang, Yuanjian Xu, Shenbin Reis, Cesar Zhang, Jianmin |
author_facet | Chen, Sheng Fang, Yuanjian Xu, Shenbin Reis, Cesar Zhang, Jianmin |
author_sort | Chen, Sheng |
collection | PubMed |
description | Mammalian Sterile20-like (MST) kinases are located upstream in the mitogen-activated protein kinase pathway, and play an important role in cell proliferation, differentiation, renewal, polarization and migration. Generally, five MST kinases exist in mammalian signal transduction pathways, including MST1, MST2, MST3, MST4 and YSK1. The central nervous system (CNS) is a sophisticated entity that takes charge of information reception, integration and response. Recently, accumulating evidence proposes that MST kinases are critical in the development of disease in different systems involving the CNS. In this review, we summarized the signal transduction pathways and interacting proteins of MST kinases. The potential biological function of each MST kinase and the commonly reported MST-related diseases in the neural system are also reviewed. Further investigation of MST kinases and their interaction with CNS diseases would provide the medical community with new therapeutic targets for human diseases. |
format | Online Article Text |
id | pubmed-5988607 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | JKL International LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-59886072018-06-12 Mammalian Sterile20-like Kinases: Signalings and Roles in Central Nervous System Chen, Sheng Fang, Yuanjian Xu, Shenbin Reis, Cesar Zhang, Jianmin Aging Dis Review Article Mammalian Sterile20-like (MST) kinases are located upstream in the mitogen-activated protein kinase pathway, and play an important role in cell proliferation, differentiation, renewal, polarization and migration. Generally, five MST kinases exist in mammalian signal transduction pathways, including MST1, MST2, MST3, MST4 and YSK1. The central nervous system (CNS) is a sophisticated entity that takes charge of information reception, integration and response. Recently, accumulating evidence proposes that MST kinases are critical in the development of disease in different systems involving the CNS. In this review, we summarized the signal transduction pathways and interacting proteins of MST kinases. The potential biological function of each MST kinase and the commonly reported MST-related diseases in the neural system are also reviewed. Further investigation of MST kinases and their interaction with CNS diseases would provide the medical community with new therapeutic targets for human diseases. JKL International LLC 2018-06-01 /pmc/articles/PMC5988607/ /pubmed/29896440 http://dx.doi.org/10.14336/AD.2017.0702 Text en Copyright: © 2018 Chen et al. http://creativecommons.org/licenses/by/2.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Review Article Chen, Sheng Fang, Yuanjian Xu, Shenbin Reis, Cesar Zhang, Jianmin Mammalian Sterile20-like Kinases: Signalings and Roles in Central Nervous System |
title | Mammalian Sterile20-like Kinases: Signalings and Roles in Central Nervous System |
title_full | Mammalian Sterile20-like Kinases: Signalings and Roles in Central Nervous System |
title_fullStr | Mammalian Sterile20-like Kinases: Signalings and Roles in Central Nervous System |
title_full_unstemmed | Mammalian Sterile20-like Kinases: Signalings and Roles in Central Nervous System |
title_short | Mammalian Sterile20-like Kinases: Signalings and Roles in Central Nervous System |
title_sort | mammalian sterile20-like kinases: signalings and roles in central nervous system |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988607/ https://www.ncbi.nlm.nih.gov/pubmed/29896440 http://dx.doi.org/10.14336/AD.2017.0702 |
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