Comparative proteomic analysis of malignant pleural mesothelioma: Focusing on the biphasic subtype

Malignant pleural mesothelioma (MPM) is a rare cancer originated from pleural mesothelial cells. MPM has been associated with long-term exposure to asbestos. In this work we performed a comparative proteomic analysis of biphasic pleural mesothelioma (B-PM). Tissue biopsies were obtained from 61 pati...

Descripción completa

Detalles Bibliográficos
Autores principales: Giusti, Laura, Ciregia, Federica, Bonotti, Alessandra, Da Valle, Ylenia, Donadio, Elena, Boldrini, Claudia, Foddis, Rudy, Giannaccini, Gino, Mazzoni, Maria R., Canessa, Pier Aldo, Cristaudo, Alfonso, Lucacchini, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Special Section: Proceedings of the 9th Annual EuPA Congress “Proteomics - Back to the Future” (June 23 - 28, 2015, Milano, Italy)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988614/
https://www.ncbi.nlm.nih.gov/pubmed/29900099
http://dx.doi.org/10.1016/j.euprot.2016.01.006
Descripción
Sumario:Malignant pleural mesothelioma (MPM) is a rare cancer originated from pleural mesothelial cells. MPM has been associated with long-term exposure to asbestos. In this work we performed a comparative proteomic analysis of biphasic pleural mesothelioma (B-PM). Tissue biopsies were obtained from 61 patients who were subjected to a diagnostic thoracoscopy. 2D/MS based approach was used for proteomic analysis. The 22 proteins found differentially expressed in B-PM, with respect to benign, were analyzed by Ingenuity Pathways Analysis and compared with those obtained for epitheliod pleural mesothelioma (E-PM). A different activation of transcription factors, proteins and cytokines were observed between two subtypes.

Ejemplares similares