Comparative proteomic analysis of malignant pleural mesothelioma: Focusing on the biphasic subtype

Malignant pleural mesothelioma (MPM) is a rare cancer originated from pleural mesothelial cells. MPM has been associated with long-term exposure to asbestos. In this work we performed a comparative proteomic analysis of biphasic pleural mesothelioma (B-PM). Tissue biopsies were obtained from 61 pati...

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Autores principales: Giusti, Laura, Ciregia, Federica, Bonotti, Alessandra, Da Valle, Ylenia, Donadio, Elena, Boldrini, Claudia, Foddis, Rudy, Giannaccini, Gino, Mazzoni, Maria R., Canessa, Pier Aldo, Cristaudo, Alfonso, Lucacchini, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Special Section: Proceedings of the 9th Annual EuPA Congress “Proteomics - Back to the Future” (June 23 - 28, 2015, Milano, Italy)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988614/
https://www.ncbi.nlm.nih.gov/pubmed/29900099
http://dx.doi.org/10.1016/j.euprot.2016.01.006
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author Giusti, Laura
Ciregia, Federica
Bonotti, Alessandra
Da Valle, Ylenia
Donadio, Elena
Boldrini, Claudia
Foddis, Rudy
Giannaccini, Gino
Mazzoni, Maria R.
Canessa, Pier Aldo
Cristaudo, Alfonso
Lucacchini, Antonio
author_facet Giusti, Laura
Ciregia, Federica
Bonotti, Alessandra
Da Valle, Ylenia
Donadio, Elena
Boldrini, Claudia
Foddis, Rudy
Giannaccini, Gino
Mazzoni, Maria R.
Canessa, Pier Aldo
Cristaudo, Alfonso
Lucacchini, Antonio
author_sort Giusti, Laura
collection PubMed
description Malignant pleural mesothelioma (MPM) is a rare cancer originated from pleural mesothelial cells. MPM has been associated with long-term exposure to asbestos. In this work we performed a comparative proteomic analysis of biphasic pleural mesothelioma (B-PM). Tissue biopsies were obtained from 61 patients who were subjected to a diagnostic thoracoscopy. 2D/MS based approach was used for proteomic analysis. The 22 proteins found differentially expressed in B-PM, with respect to benign, were analyzed by Ingenuity Pathways Analysis and compared with those obtained for epitheliod pleural mesothelioma (E-PM). A different activation of transcription factors, proteins and cytokines were observed between two subtypes.
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spelling pubmed-59886142018-06-13 Comparative proteomic analysis of malignant pleural mesothelioma: Focusing on the biphasic subtype Giusti, Laura Ciregia, Federica Bonotti, Alessandra Da Valle, Ylenia Donadio, Elena Boldrini, Claudia Foddis, Rudy Giannaccini, Gino Mazzoni, Maria R. Canessa, Pier Aldo Cristaudo, Alfonso Lucacchini, Antonio EuPA Open Proteom Special Section: Proceedings of the 9th Annual EuPA Congress “Proteomics - Back to the Future” (June 23 - 28, 2015, Milano, Italy) Malignant pleural mesothelioma (MPM) is a rare cancer originated from pleural mesothelial cells. MPM has been associated with long-term exposure to asbestos. In this work we performed a comparative proteomic analysis of biphasic pleural mesothelioma (B-PM). Tissue biopsies were obtained from 61 patients who were subjected to a diagnostic thoracoscopy. 2D/MS based approach was used for proteomic analysis. The 22 proteins found differentially expressed in B-PM, with respect to benign, were analyzed by Ingenuity Pathways Analysis and compared with those obtained for epitheliod pleural mesothelioma (E-PM). A different activation of transcription factors, proteins and cytokines were observed between two subtypes. Elsevier 2016-01-16 /pmc/articles/PMC5988614/ /pubmed/29900099 http://dx.doi.org/10.1016/j.euprot.2016.01.006 Text en © 2016 The Authors. Published by Elsevier B.V. on behalf of European Proteomics Association (EuPA). http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Special Section: Proceedings of the 9th Annual EuPA Congress “Proteomics - Back to the Future” (June 23 - 28, 2015, Milano, Italy)
Giusti, Laura
Ciregia, Federica
Bonotti, Alessandra
Da Valle, Ylenia
Donadio, Elena
Boldrini, Claudia
Foddis, Rudy
Giannaccini, Gino
Mazzoni, Maria R.
Canessa, Pier Aldo
Cristaudo, Alfonso
Lucacchini, Antonio
Comparative proteomic analysis of malignant pleural mesothelioma: Focusing on the biphasic subtype
title Comparative proteomic analysis of malignant pleural mesothelioma: Focusing on the biphasic subtype
title_full Comparative proteomic analysis of malignant pleural mesothelioma: Focusing on the biphasic subtype
title_fullStr Comparative proteomic analysis of malignant pleural mesothelioma: Focusing on the biphasic subtype
title_full_unstemmed Comparative proteomic analysis of malignant pleural mesothelioma: Focusing on the biphasic subtype
title_short Comparative proteomic analysis of malignant pleural mesothelioma: Focusing on the biphasic subtype
title_sort comparative proteomic analysis of malignant pleural mesothelioma: focusing on the biphasic subtype
topic Special Section: Proceedings of the 9th Annual EuPA Congress “Proteomics - Back to the Future” (June 23 - 28, 2015, Milano, Italy)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988614/
https://www.ncbi.nlm.nih.gov/pubmed/29900099
http://dx.doi.org/10.1016/j.euprot.2016.01.006
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