HEV ORF3 downregulates TLR7 to inhibit the generation of type I interferon via impairment of multiple signaling pathways

Hepatitis E is the most common type of acute hepatitis prevalent worldwide. The open reading frame 3 protein of HEV (HEV ORF3) is proposed to create a favorable environment for viral replication and pathogenesis. However, the mechanisms by which HEV overcomes the effects of host immunity, particular...

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Detalles Bibliográficos
Autores principales: Lei, Qingsong, Li, Lin, Zhang, Shujun, Li, Tianju, Zhang, Xiaomei, Ding, Xiaolin, Qin, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988675/
https://www.ncbi.nlm.nih.gov/pubmed/29872132
http://dx.doi.org/10.1038/s41598-018-26975-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988675/
https://www.ncbi.nlm.nih.gov/pubmed/29872132
http://dx.doi.org/10.1038/s41598-018-26975-4

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