Have compensatory mutations facilitated the current epidemic of multidrug-resistant tuberculosis?

Compensatory mutations have been suggested to promote multidrug-resistant tuberculosis (MDR-TB) transmission, but their role in facilitating the recent transmission of MDR-TB is unclear. To investigate the epidemiological significance of compensatory mutations, we analyzed a four-year population-bas...

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Autores principales: Liu, Qingyun, Zuo, Tianyu, Xu, Peng, Jiang, Qi, Wu, Jie, Gan, Mingyu, Yang, Chongguang, Prakash, Ravi, Zhu, Guofeng, Takiff, Howard E., Gao, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988693/
https://www.ncbi.nlm.nih.gov/pubmed/29872078
http://dx.doi.org/10.1038/s41426-018-0101-6
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author Liu, Qingyun
Zuo, Tianyu
Xu, Peng
Jiang, Qi
Wu, Jie
Gan, Mingyu
Yang, Chongguang
Prakash, Ravi
Zhu, Guofeng
Takiff, Howard E.
Gao, Qian
author_facet Liu, Qingyun
Zuo, Tianyu
Xu, Peng
Jiang, Qi
Wu, Jie
Gan, Mingyu
Yang, Chongguang
Prakash, Ravi
Zhu, Guofeng
Takiff, Howard E.
Gao, Qian
author_sort Liu, Qingyun
collection PubMed
description Compensatory mutations have been suggested to promote multidrug-resistant tuberculosis (MDR-TB) transmission, but their role in facilitating the recent transmission of MDR-TB is unclear. To investigate the epidemiological significance of compensatory mutations, we analyzed a four-year population-based collection of MDR-TB strains from Shanghai (the most populous city in China) and 1346 published global MDR-TB strains. We report that MDR-TB strains with compensatory mutations in the rpoA, rpoB, or rpoC genes were neither more frequently clustered nor found in larger clusters than those without compensatory mutations. Our results suggest that compensatory mutations are not a major contributor to the current epidemic of MDR-TB.
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spelling pubmed-59886932018-06-06 Have compensatory mutations facilitated the current epidemic of multidrug-resistant tuberculosis? Liu, Qingyun Zuo, Tianyu Xu, Peng Jiang, Qi Wu, Jie Gan, Mingyu Yang, Chongguang Prakash, Ravi Zhu, Guofeng Takiff, Howard E. Gao, Qian Emerg Microbes Infect Article Compensatory mutations have been suggested to promote multidrug-resistant tuberculosis (MDR-TB) transmission, but their role in facilitating the recent transmission of MDR-TB is unclear. To investigate the epidemiological significance of compensatory mutations, we analyzed a four-year population-based collection of MDR-TB strains from Shanghai (the most populous city in China) and 1346 published global MDR-TB strains. We report that MDR-TB strains with compensatory mutations in the rpoA, rpoB, or rpoC genes were neither more frequently clustered nor found in larger clusters than those without compensatory mutations. Our results suggest that compensatory mutations are not a major contributor to the current epidemic of MDR-TB. Nature Publishing Group UK 2018-06-06 /pmc/articles/PMC5988693/ /pubmed/29872078 http://dx.doi.org/10.1038/s41426-018-0101-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Liu, Qingyun
Zuo, Tianyu
Xu, Peng
Jiang, Qi
Wu, Jie
Gan, Mingyu
Yang, Chongguang
Prakash, Ravi
Zhu, Guofeng
Takiff, Howard E.
Gao, Qian
Have compensatory mutations facilitated the current epidemic of multidrug-resistant tuberculosis?
title Have compensatory mutations facilitated the current epidemic of multidrug-resistant tuberculosis?
title_full Have compensatory mutations facilitated the current epidemic of multidrug-resistant tuberculosis?
title_fullStr Have compensatory mutations facilitated the current epidemic of multidrug-resistant tuberculosis?
title_full_unstemmed Have compensatory mutations facilitated the current epidemic of multidrug-resistant tuberculosis?
title_short Have compensatory mutations facilitated the current epidemic of multidrug-resistant tuberculosis?
title_sort have compensatory mutations facilitated the current epidemic of multidrug-resistant tuberculosis?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988693/
https://www.ncbi.nlm.nih.gov/pubmed/29872078
http://dx.doi.org/10.1038/s41426-018-0101-6
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