EGFR controls bone development by negatively regulating mTOR-signaling during osteoblast differentiation

Mice deficient in epidermal growth factor receptor (Egfr(−/−) mice) are growth retarded and exhibit severe bone defects that are poorly understood. Here we show that EGFR-deficient mice are osteopenic and display impaired endochondral and intramembranous ossification resulting in irregular mineraliz...

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Detalles Bibliográficos
Autores principales: Linder, Markus, Hecking, Manfred, Glitzner, Elisabeth, Zwerina, Karin, Holcmann, Martin, Bakiri, Latifa, Ruocco, Maria Grazia, Tuckermann, Jan, Schett, Georg, Wagner, Erwin F., Sibilia, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988706/
https://www.ncbi.nlm.nih.gov/pubmed/29445126
http://dx.doi.org/10.1038/s41418-017-0054-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988706/
https://www.ncbi.nlm.nih.gov/pubmed/29445126
http://dx.doi.org/10.1038/s41418-017-0054-7

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