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A novel risk score for hepatocellular carcinoma in Asian cirrhotic patients: a multicentre prospective cohort study
Liver cirrhotic patients suffer from a seemingly unpredictable risk of hepatocellular carcinoma (HCC). Here, an HCC risk score R (0 ≦ R ≦ 1) was derived from commonly tested haematological and biochemical parameters. In the score-derivation Taiwanese cohort (144 cirrhosis versus 48 HCC-remission pat...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988718/ https://www.ncbi.nlm.nih.gov/pubmed/29872158 http://dx.doi.org/10.1038/s41598-018-26992-3 |
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author | Liang, Kung-Hao Ahn, Sang Hoon Lee, Hye Wong Huang, Ya-Hui Chien, Rong-Nan Hu, Tsung-Hui Lin, Kwang-Huei Yeh, Christopher Sung-Huan Hsu, Chao-Wei Lin, Chih-Lang Pan, Tai-Long Ke, Po-Yuan Chang, Ming-Ling Yeh, Chau-Ting |
author_facet | Liang, Kung-Hao Ahn, Sang Hoon Lee, Hye Wong Huang, Ya-Hui Chien, Rong-Nan Hu, Tsung-Hui Lin, Kwang-Huei Yeh, Christopher Sung-Huan Hsu, Chao-Wei Lin, Chih-Lang Pan, Tai-Long Ke, Po-Yuan Chang, Ming-Ling Yeh, Chau-Ting |
author_sort | Liang, Kung-Hao |
collection | PubMed |
description | Liver cirrhotic patients suffer from a seemingly unpredictable risk of hepatocellular carcinoma (HCC). Here, an HCC risk score R (0 ≦ R ≦ 1) was derived from commonly tested haematological and biochemical parameters. In the score-derivation Taiwanese cohort (144 cirrhosis versus 48 HCC-remission patients), the score had an area-under-the-curve (AUC) of 0.70 (95% confidence interval [CI], 0.61–0.78, P < 0.001). When validated in a Korean cohort (78 cirrhosis versus 23 HCC-remission patients), the AUC was 0.68 (CI, 0.56–0.80, P = 0.009). In a multicentre prospective cohort (478 cirrhotic patients prospectively followed for HCC occurrence), the hazard ratio with respect to R was 2.344 (CI = 1.183–4.646, P = 0.015). The cumulative incidences of HCC at two years after patient enrolment were 9.6% and 1.7% for the high-risk (R ≧ 0.5) and low-risk (R < 0.5) groups, respectively (P < 0.001). At the end of the study, the incidences were 10.9% and 5.0%, respectively (P = 0.012). The majority of HCCs (23/26) in the high-risk group emerged within the first two years of follow-up. In conclusion, an HCC risk score was developed for cirrhotic patients that effectively predicted HCC in a prospective cohort study. |
format | Online Article Text |
id | pubmed-5988718 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-59887182018-06-20 A novel risk score for hepatocellular carcinoma in Asian cirrhotic patients: a multicentre prospective cohort study Liang, Kung-Hao Ahn, Sang Hoon Lee, Hye Wong Huang, Ya-Hui Chien, Rong-Nan Hu, Tsung-Hui Lin, Kwang-Huei Yeh, Christopher Sung-Huan Hsu, Chao-Wei Lin, Chih-Lang Pan, Tai-Long Ke, Po-Yuan Chang, Ming-Ling Yeh, Chau-Ting Sci Rep Article Liver cirrhotic patients suffer from a seemingly unpredictable risk of hepatocellular carcinoma (HCC). Here, an HCC risk score R (0 ≦ R ≦ 1) was derived from commonly tested haematological and biochemical parameters. In the score-derivation Taiwanese cohort (144 cirrhosis versus 48 HCC-remission patients), the score had an area-under-the-curve (AUC) of 0.70 (95% confidence interval [CI], 0.61–0.78, P < 0.001). When validated in a Korean cohort (78 cirrhosis versus 23 HCC-remission patients), the AUC was 0.68 (CI, 0.56–0.80, P = 0.009). In a multicentre prospective cohort (478 cirrhotic patients prospectively followed for HCC occurrence), the hazard ratio with respect to R was 2.344 (CI = 1.183–4.646, P = 0.015). The cumulative incidences of HCC at two years after patient enrolment were 9.6% and 1.7% for the high-risk (R ≧ 0.5) and low-risk (R < 0.5) groups, respectively (P < 0.001). At the end of the study, the incidences were 10.9% and 5.0%, respectively (P = 0.012). The majority of HCCs (23/26) in the high-risk group emerged within the first two years of follow-up. In conclusion, an HCC risk score was developed for cirrhotic patients that effectively predicted HCC in a prospective cohort study. Nature Publishing Group UK 2018-06-05 /pmc/articles/PMC5988718/ /pubmed/29872158 http://dx.doi.org/10.1038/s41598-018-26992-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Liang, Kung-Hao Ahn, Sang Hoon Lee, Hye Wong Huang, Ya-Hui Chien, Rong-Nan Hu, Tsung-Hui Lin, Kwang-Huei Yeh, Christopher Sung-Huan Hsu, Chao-Wei Lin, Chih-Lang Pan, Tai-Long Ke, Po-Yuan Chang, Ming-Ling Yeh, Chau-Ting A novel risk score for hepatocellular carcinoma in Asian cirrhotic patients: a multicentre prospective cohort study |
title | A novel risk score for hepatocellular carcinoma in Asian cirrhotic patients: a multicentre prospective cohort study |
title_full | A novel risk score for hepatocellular carcinoma in Asian cirrhotic patients: a multicentre prospective cohort study |
title_fullStr | A novel risk score for hepatocellular carcinoma in Asian cirrhotic patients: a multicentre prospective cohort study |
title_full_unstemmed | A novel risk score for hepatocellular carcinoma in Asian cirrhotic patients: a multicentre prospective cohort study |
title_short | A novel risk score for hepatocellular carcinoma in Asian cirrhotic patients: a multicentre prospective cohort study |
title_sort | novel risk score for hepatocellular carcinoma in asian cirrhotic patients: a multicentre prospective cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988718/ https://www.ncbi.nlm.nih.gov/pubmed/29872158 http://dx.doi.org/10.1038/s41598-018-26992-3 |
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