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A novel risk score for hepatocellular carcinoma in Asian cirrhotic patients: a multicentre prospective cohort study

Liver cirrhotic patients suffer from a seemingly unpredictable risk of hepatocellular carcinoma (HCC). Here, an HCC risk score R (0 ≦ R ≦ 1) was derived from commonly tested haematological and biochemical parameters. In the score-derivation Taiwanese cohort (144 cirrhosis versus 48 HCC-remission pat...

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Autores principales: Liang, Kung-Hao, Ahn, Sang Hoon, Lee, Hye Wong, Huang, Ya-Hui, Chien, Rong-Nan, Hu, Tsung-Hui, Lin, Kwang-Huei, Yeh, Christopher Sung-Huan, Hsu, Chao-Wei, Lin, Chih-Lang, Pan, Tai-Long, Ke, Po-Yuan, Chang, Ming-Ling, Yeh, Chau-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988718/
https://www.ncbi.nlm.nih.gov/pubmed/29872158
http://dx.doi.org/10.1038/s41598-018-26992-3
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author Liang, Kung-Hao
Ahn, Sang Hoon
Lee, Hye Wong
Huang, Ya-Hui
Chien, Rong-Nan
Hu, Tsung-Hui
Lin, Kwang-Huei
Yeh, Christopher Sung-Huan
Hsu, Chao-Wei
Lin, Chih-Lang
Pan, Tai-Long
Ke, Po-Yuan
Chang, Ming-Ling
Yeh, Chau-Ting
author_facet Liang, Kung-Hao
Ahn, Sang Hoon
Lee, Hye Wong
Huang, Ya-Hui
Chien, Rong-Nan
Hu, Tsung-Hui
Lin, Kwang-Huei
Yeh, Christopher Sung-Huan
Hsu, Chao-Wei
Lin, Chih-Lang
Pan, Tai-Long
Ke, Po-Yuan
Chang, Ming-Ling
Yeh, Chau-Ting
author_sort Liang, Kung-Hao
collection PubMed
description Liver cirrhotic patients suffer from a seemingly unpredictable risk of hepatocellular carcinoma (HCC). Here, an HCC risk score R (0 ≦ R ≦ 1) was derived from commonly tested haematological and biochemical parameters. In the score-derivation Taiwanese cohort (144 cirrhosis versus 48 HCC-remission patients), the score had an area-under-the-curve (AUC) of 0.70 (95% confidence interval [CI], 0.61–0.78, P < 0.001). When validated in a Korean cohort (78 cirrhosis versus 23 HCC-remission patients), the AUC was 0.68 (CI, 0.56–0.80, P = 0.009). In a multicentre prospective cohort (478 cirrhotic patients prospectively followed for HCC occurrence), the hazard ratio with respect to R was 2.344 (CI = 1.183–4.646, P = 0.015). The cumulative incidences of HCC at two years after patient enrolment were 9.6% and 1.7% for the high-risk (R ≧ 0.5) and low-risk (R < 0.5) groups, respectively (P < 0.001). At the end of the study, the incidences were 10.9% and 5.0%, respectively (P = 0.012). The majority of HCCs (23/26) in the high-risk group emerged within the first two years of follow-up. In conclusion, an HCC risk score was developed for cirrhotic patients that effectively predicted HCC in a prospective cohort study.
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spelling pubmed-59887182018-06-20 A novel risk score for hepatocellular carcinoma in Asian cirrhotic patients: a multicentre prospective cohort study Liang, Kung-Hao Ahn, Sang Hoon Lee, Hye Wong Huang, Ya-Hui Chien, Rong-Nan Hu, Tsung-Hui Lin, Kwang-Huei Yeh, Christopher Sung-Huan Hsu, Chao-Wei Lin, Chih-Lang Pan, Tai-Long Ke, Po-Yuan Chang, Ming-Ling Yeh, Chau-Ting Sci Rep Article Liver cirrhotic patients suffer from a seemingly unpredictable risk of hepatocellular carcinoma (HCC). Here, an HCC risk score R (0 ≦ R ≦ 1) was derived from commonly tested haematological and biochemical parameters. In the score-derivation Taiwanese cohort (144 cirrhosis versus 48 HCC-remission patients), the score had an area-under-the-curve (AUC) of 0.70 (95% confidence interval [CI], 0.61–0.78, P < 0.001). When validated in a Korean cohort (78 cirrhosis versus 23 HCC-remission patients), the AUC was 0.68 (CI, 0.56–0.80, P = 0.009). In a multicentre prospective cohort (478 cirrhotic patients prospectively followed for HCC occurrence), the hazard ratio with respect to R was 2.344 (CI = 1.183–4.646, P = 0.015). The cumulative incidences of HCC at two years after patient enrolment were 9.6% and 1.7% for the high-risk (R ≧ 0.5) and low-risk (R < 0.5) groups, respectively (P < 0.001). At the end of the study, the incidences were 10.9% and 5.0%, respectively (P = 0.012). The majority of HCCs (23/26) in the high-risk group emerged within the first two years of follow-up. In conclusion, an HCC risk score was developed for cirrhotic patients that effectively predicted HCC in a prospective cohort study. Nature Publishing Group UK 2018-06-05 /pmc/articles/PMC5988718/ /pubmed/29872158 http://dx.doi.org/10.1038/s41598-018-26992-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Liang, Kung-Hao
Ahn, Sang Hoon
Lee, Hye Wong
Huang, Ya-Hui
Chien, Rong-Nan
Hu, Tsung-Hui
Lin, Kwang-Huei
Yeh, Christopher Sung-Huan
Hsu, Chao-Wei
Lin, Chih-Lang
Pan, Tai-Long
Ke, Po-Yuan
Chang, Ming-Ling
Yeh, Chau-Ting
A novel risk score for hepatocellular carcinoma in Asian cirrhotic patients: a multicentre prospective cohort study
title A novel risk score for hepatocellular carcinoma in Asian cirrhotic patients: a multicentre prospective cohort study
title_full A novel risk score for hepatocellular carcinoma in Asian cirrhotic patients: a multicentre prospective cohort study
title_fullStr A novel risk score for hepatocellular carcinoma in Asian cirrhotic patients: a multicentre prospective cohort study
title_full_unstemmed A novel risk score for hepatocellular carcinoma in Asian cirrhotic patients: a multicentre prospective cohort study
title_short A novel risk score for hepatocellular carcinoma in Asian cirrhotic patients: a multicentre prospective cohort study
title_sort novel risk score for hepatocellular carcinoma in asian cirrhotic patients: a multicentre prospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988718/
https://www.ncbi.nlm.nih.gov/pubmed/29872158
http://dx.doi.org/10.1038/s41598-018-26992-3
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