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Prior activity of olfactory receptor neurons is required for proper sensory processing and behavior in Drosophila larvae
Animal responses to their environment rely on activation of sensory neurons by external stimuli. In many sensory systems, however, neurons display basal activity prior to the external stimuli. This prior activity is thought to modulate neural functions, yet its impact on animal behavior remains elus...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988719/ https://www.ncbi.nlm.nih.gov/pubmed/29872087 http://dx.doi.org/10.1038/s41598-018-26825-3 |
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author | Utashiro, Nao Williams, Claire R. Parrish, Jay Z. Emoto, Kazuo |
author_facet | Utashiro, Nao Williams, Claire R. Parrish, Jay Z. Emoto, Kazuo |
author_sort | Utashiro, Nao |
collection | PubMed |
description | Animal responses to their environment rely on activation of sensory neurons by external stimuli. In many sensory systems, however, neurons display basal activity prior to the external stimuli. This prior activity is thought to modulate neural functions, yet its impact on animal behavior remains elusive. Here, we reveal a potential role for prior activity in olfactory receptor neurons (ORNs) in shaping larval olfactory behavior. We show that prior activity in larval ORNs is mediated by the olfactory receptor complex (OR complex). Mutations of Orco, an odorant co-receptor required for OR complex function, cause reduced attractive behavior in response to optogenetic activation of ORNs. Calcium imaging reveals that Orco mutant ORNs fully respond to optogenetic stimulation but exhibit altered temporal patterns of neural responses. These findings together suggest a critical role for prior activity in information processing upon ORN activation in Drosophila larvae, which in turn contributes to olfactory behavior control. |
format | Online Article Text |
id | pubmed-5988719 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-59887192018-06-20 Prior activity of olfactory receptor neurons is required for proper sensory processing and behavior in Drosophila larvae Utashiro, Nao Williams, Claire R. Parrish, Jay Z. Emoto, Kazuo Sci Rep Article Animal responses to their environment rely on activation of sensory neurons by external stimuli. In many sensory systems, however, neurons display basal activity prior to the external stimuli. This prior activity is thought to modulate neural functions, yet its impact on animal behavior remains elusive. Here, we reveal a potential role for prior activity in olfactory receptor neurons (ORNs) in shaping larval olfactory behavior. We show that prior activity in larval ORNs is mediated by the olfactory receptor complex (OR complex). Mutations of Orco, an odorant co-receptor required for OR complex function, cause reduced attractive behavior in response to optogenetic activation of ORNs. Calcium imaging reveals that Orco mutant ORNs fully respond to optogenetic stimulation but exhibit altered temporal patterns of neural responses. These findings together suggest a critical role for prior activity in information processing upon ORN activation in Drosophila larvae, which in turn contributes to olfactory behavior control. Nature Publishing Group UK 2018-06-05 /pmc/articles/PMC5988719/ /pubmed/29872087 http://dx.doi.org/10.1038/s41598-018-26825-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Utashiro, Nao Williams, Claire R. Parrish, Jay Z. Emoto, Kazuo Prior activity of olfactory receptor neurons is required for proper sensory processing and behavior in Drosophila larvae |
title | Prior activity of olfactory receptor neurons is required for proper sensory processing and behavior in Drosophila larvae |
title_full | Prior activity of olfactory receptor neurons is required for proper sensory processing and behavior in Drosophila larvae |
title_fullStr | Prior activity of olfactory receptor neurons is required for proper sensory processing and behavior in Drosophila larvae |
title_full_unstemmed | Prior activity of olfactory receptor neurons is required for proper sensory processing and behavior in Drosophila larvae |
title_short | Prior activity of olfactory receptor neurons is required for proper sensory processing and behavior in Drosophila larvae |
title_sort | prior activity of olfactory receptor neurons is required for proper sensory processing and behavior in drosophila larvae |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988719/ https://www.ncbi.nlm.nih.gov/pubmed/29872087 http://dx.doi.org/10.1038/s41598-018-26825-3 |
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