Neuromelanin organelles are specialized autolysosomes that accumulate undegraded proteins and lipids in aging human brain and are likely involved in Parkinson’s disease

During aging, neuronal organelles filled with neuromelanin (a dark-brown pigment) and lipid bodies accumulate in the brain, particularly in the substantia nigra, a region targeted in Parkinson’s disease. We have investigated protein and lipid systems involved in the formation of these organelles and...

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Detalles Bibliográficos
Autores principales: Zucca, Fabio A., Vanna, Renzo, Cupaioli, Francesca A., Bellei, Chiara, De Palma, Antonella, Di Silvestre, Dario, Mauri, Pierluigi, Grassi, Sara, Prinetti, Alessandro, Casella, Luigi, Sulzer, David, Zecca, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988730/
https://www.ncbi.nlm.nih.gov/pubmed/29900402
http://dx.doi.org/10.1038/s41531-018-0050-8

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