Variable number of TMC1-dependent mechanotransducer channels underlie tonotopic conductance gradients in the cochlea

Functional mechanoelectrical transduction (MET) channels of cochlear hair cells require the presence of transmembrane channel-like protein isoforms TMC1 or TMC2. We show that TMCs are required for normal stereociliary bundle development and distinctively influence channel properties. TMC1-dependent...

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Detalles Bibliográficos
Autores principales: Beurg, Maryline, Cui, Runjia, Goldring, Adam C., Ebrahim, Seham, Fettiplace, Robert, Kachar, Bechara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988745/
https://www.ncbi.nlm.nih.gov/pubmed/29872055
http://dx.doi.org/10.1038/s41467-018-04589-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988745/
https://www.ncbi.nlm.nih.gov/pubmed/29872055
http://dx.doi.org/10.1038/s41467-018-04589-8

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