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Psoriasin, a novel anti-Candida albicans adhesin
ABSTRACT: Candida albicans belongs to the normal microbial flora on epithelial surfaces of humans. However, under certain, still not fully understood conditions, it can become pathogenic and cause a spectrum of diseases, from local infections to life-threatening septicemia. We investigated a panel o...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988767/ https://www.ncbi.nlm.nih.gov/pubmed/29736603 http://dx.doi.org/10.1007/s00109-018-1637-6 |
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author | Brauner, Annelie Alvendal, Cathrin Chromek, Milan Stopsack, Konrad H. Ehrström, Sophia Schröder, Jens M. Bohm-Starke, Nina |
author_facet | Brauner, Annelie Alvendal, Cathrin Chromek, Milan Stopsack, Konrad H. Ehrström, Sophia Schröder, Jens M. Bohm-Starke, Nina |
author_sort | Brauner, Annelie |
collection | PubMed |
description | ABSTRACT: Candida albicans belongs to the normal microbial flora on epithelial surfaces of humans. However, under certain, still not fully understood conditions, it can become pathogenic and cause a spectrum of diseases, from local infections to life-threatening septicemia. We investigated a panel of antimicrobial proteins and peptides (AMPs), potentially involved in mucosal immunity against this pathogen. Out of six studied AMPs, psoriasin was most up-regulated during a mucosal infection, an acute episode of recurrent Candida vulvovaginitis, although candidacidal activity has not been demonstrated. We here show that psoriasin binds to β-glucan, a basic component of the C. albicans cell wall, and thereby inhibits adhesion of the pathogen to surfaces and increases IL-8 production by mucosal epithelial cells. In conclusion, we show a novel mechanism of action of psoriasin. By inhibiting C. albicans adhesion and by enhancing cytokine production, psoriasin contributes to the immune response against C. albicans. KEY MESSAGES: The antimicrobial peptide psoriasin is highly up-regulated during a local mucosal infection, Candida albicans vulvovaginitis. Psoriasin binds to β-glucan in the Candida albicans cell wall and thereby inhibits adhesion of the pathogen. Binding of psoriasin to Candida albicans induces an immune response by mucosal epithelial cells. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00109-018-1637-6) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5988767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-59887672018-06-12 Psoriasin, a novel anti-Candida albicans adhesin Brauner, Annelie Alvendal, Cathrin Chromek, Milan Stopsack, Konrad H. Ehrström, Sophia Schröder, Jens M. Bohm-Starke, Nina J Mol Med (Berl) Original Article ABSTRACT: Candida albicans belongs to the normal microbial flora on epithelial surfaces of humans. However, under certain, still not fully understood conditions, it can become pathogenic and cause a spectrum of diseases, from local infections to life-threatening septicemia. We investigated a panel of antimicrobial proteins and peptides (AMPs), potentially involved in mucosal immunity against this pathogen. Out of six studied AMPs, psoriasin was most up-regulated during a mucosal infection, an acute episode of recurrent Candida vulvovaginitis, although candidacidal activity has not been demonstrated. We here show that psoriasin binds to β-glucan, a basic component of the C. albicans cell wall, and thereby inhibits adhesion of the pathogen to surfaces and increases IL-8 production by mucosal epithelial cells. In conclusion, we show a novel mechanism of action of psoriasin. By inhibiting C. albicans adhesion and by enhancing cytokine production, psoriasin contributes to the immune response against C. albicans. KEY MESSAGES: The antimicrobial peptide psoriasin is highly up-regulated during a local mucosal infection, Candida albicans vulvovaginitis. Psoriasin binds to β-glucan in the Candida albicans cell wall and thereby inhibits adhesion of the pathogen. Binding of psoriasin to Candida albicans induces an immune response by mucosal epithelial cells. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00109-018-1637-6) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2018-05-07 2018 /pmc/articles/PMC5988767/ /pubmed/29736603 http://dx.doi.org/10.1007/s00109-018-1637-6 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Brauner, Annelie Alvendal, Cathrin Chromek, Milan Stopsack, Konrad H. Ehrström, Sophia Schröder, Jens M. Bohm-Starke, Nina Psoriasin, a novel anti-Candida albicans adhesin |
title | Psoriasin, a novel anti-Candida albicans adhesin |
title_full | Psoriasin, a novel anti-Candida albicans adhesin |
title_fullStr | Psoriasin, a novel anti-Candida albicans adhesin |
title_full_unstemmed | Psoriasin, a novel anti-Candida albicans adhesin |
title_short | Psoriasin, a novel anti-Candida albicans adhesin |
title_sort | psoriasin, a novel anti-candida albicans adhesin |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988767/ https://www.ncbi.nlm.nih.gov/pubmed/29736603 http://dx.doi.org/10.1007/s00109-018-1637-6 |
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