Microbial networking in cancer: when two toxins collide

A recent study by Dejea et al. has demonstrated that two enterotoxigenic bacteria frequently associated with sporadic colorectal cancer, Bacteroides fragilis and pks+ Escherichia coli, are found together in biofilms on tissue from patients with familial adenomatous polyposis. In preclinical mouse mo...

Descripción completa

Detalles Bibliográficos
Autores principales: Tomkovich, Sarah, Jobin, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988818/
https://www.ncbi.nlm.nih.gov/pubmed/29773837
http://dx.doi.org/10.1038/s41416-018-0101-2
_version_ 1783329355391303680
author Tomkovich, Sarah
Jobin, Christian
author_facet Tomkovich, Sarah
Jobin, Christian
author_sort Tomkovich, Sarah
collection PubMed
description A recent study by Dejea et al. has demonstrated that two enterotoxigenic bacteria frequently associated with sporadic colorectal cancer, Bacteroides fragilis and pks+ Escherichia coli, are found together in biofilms on tissue from patients with familial adenomatous polyposis. In preclinical mouse models, these two bacteria and their corresponding toxins work synergistically to promote colon cancer.
format Online
Article
Text
id pubmed-5988818
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-59888182019-07-03 Microbial networking in cancer: when two toxins collide Tomkovich, Sarah Jobin, Christian Br J Cancer Editorial A recent study by Dejea et al. has demonstrated that two enterotoxigenic bacteria frequently associated with sporadic colorectal cancer, Bacteroides fragilis and pks+ Escherichia coli, are found together in biofilms on tissue from patients with familial adenomatous polyposis. In preclinical mouse models, these two bacteria and their corresponding toxins work synergistically to promote colon cancer. Nature Publishing Group UK 2018-05-18 2018-05-29 /pmc/articles/PMC5988818/ /pubmed/29773837 http://dx.doi.org/10.1038/s41416-018-0101-2 Text en © Cancer Research UK 2018 https://creativecommons.org/licenses/by-nc-sa/4.0/Note: This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License.)
spellingShingle Editorial
Tomkovich, Sarah
Jobin, Christian
Microbial networking in cancer: when two toxins collide
title Microbial networking in cancer: when two toxins collide
title_full Microbial networking in cancer: when two toxins collide
title_fullStr Microbial networking in cancer: when two toxins collide
title_full_unstemmed Microbial networking in cancer: when two toxins collide
title_short Microbial networking in cancer: when two toxins collide
title_sort microbial networking in cancer: when two toxins collide
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988818/
https://www.ncbi.nlm.nih.gov/pubmed/29773837
http://dx.doi.org/10.1038/s41416-018-0101-2
work_keys_str_mv AT tomkovichsarah microbialnetworkingincancerwhentwotoxinscollide
AT jobinchristian microbialnetworkingincancerwhentwotoxinscollide

Ejemplares similares