Cargando…

Computer Simulation of TSP1 Inhibition of VEGF–Akt–eNOS: An Angiogenesis Triple Threat

The matricellular protein thrombospondin-1 (TSP1) is a potent inhibitor of angiogenesis. Specifically, TSP1 has been experimentally shown to inhibit signaling downstream of vascular endothelial growth factor (VEGF). The molecular mechanism of this inhibition is not entirely clear. We developed a det...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bazzazi, Hojjat, Zhang, Yu, Jafarnejad, Mohammad, Isenberg, Jeffrey S., Annex, Brian H., Popel, Aleksander S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988849/ https://www.ncbi.nlm.nih.gov/pubmed/29899706 http://dx.doi.org/10.3389/fphys.2018.00644

Ejemplares similares

Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation
por: Bazzazi, Hojjat, et al.
Publicado: (2017)

Corrigendum: Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation
por: Bazzazi, Hojjat, et al.
Publicado: (2017)

Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells
por: Bazzazi, Hojjat, et al.
Publicado: (2017)

ADAMTS-1 inhibits angiogenesis via the PI3K/Akt-eNOS-VEGF pathway in lung cancer cells
por: Wang, Bu, et al.
Publicado: (2019)

High-Fat Diet-Induced Obesity Model Does Not Promote Endothelial Dysfunction via Increasing Leptin/Akt/eNOS Signaling
por: Rocha, Vanessa da Silva, et al.
Publicado: (2019)

Voluntary exercise does not increase gastrointestinal motility but increases spatial memory, intestinal eNOS, Akt levels, and Bifidobacteria abundance in the microbiome
por: Bakonyi, Peter, et al.
Publicado: (2023)

Obesity, Inflammation, and Exercise Training: Relative Contribution of iNOS and eNOS in the Modulation of Vascular Function in the Mouse Aorta
por: Silva, Josiane F., et al.
Publicado: (2016)

Trichosanthes pericarpium Aqueous Extract Enhances the Mobilization of Endothelial Progenitor Cells and Up-regulates the Expression of VEGF, eNOS, NO, and MMP-9 in Acute Myocardial Ischemic Rats
por: Fu, Nini, et al.
Publicado: (2018)

The Emerging Role of Hepatocellular eNOS in Non-alcoholic Fatty Liver Disease Development
por: Cunningham, Rory P., et al.
Publicado: (2020)

Rhynchophylline Ameliorates Endothelial Dysfunction via Src-PI3K/Akt-eNOS Cascade in the Cultured Intrarenal Arteries of Spontaneous Hypertensive Rats
por: Hao, Hui-Feng, et al.
Publicado: (2017)

Marine Compound Catunaregin Inhibits Angiogenesis through the Modulation of Phosphorylation of Akt and eNOS in vivo and in vitro
por: Liu, Jun-Xiu, et al.
Publicado: (2014)

Grape Seed Extract Polyphenols Improve Resistance Artery Function in Pregnant eNOS(–/–) Mice
por: Tropea, Teresa, et al.
Publicado: (2020)

Radix Astragalus Polysaccharide Accelerates Angiogenesis by Activating AKT/eNOS to Promote Nerve Regeneration and Functional Recovery
por: Zhang, Geyi, et al.
Publicado: (2022)

Endothelial S1pr2 regulates post-ischemic angiogenesis via AKT/eNOS signaling pathway
por: Zhou, Caixia, et al.
Publicado: (2022)

Mathematical Model Predicts Effective Strategies to Inhibit VEGF-eNOS Signaling
por: Wu, Qianhui, et al.
Publicado: (2020)

Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis
por: Vempati, Prakash, et al.
Publicado: (2011)

Tocomin Restores Endothelium-Dependent Relaxation in the Diabetic Rat Aorta by Increasing NO Bioavailability and Improving the Expression of eNOS
por: Ali, Saher F., et al.
Publicado: (2019)

Crocetin promotes angiogenesis in human endothelial cells through PI3K-Akt-eNOS signaling pathway
por: Nasirzadeh, Mahdieh, et al.
Publicado: (2019)

Tongxinluo Protects against Pressure Overload–Induced Heart Failure in Mice Involving VEGF/Akt/eNOS Pathway Activation
por: Wang, Bo, et al.
Publicado: (2014)

Angiogenesis in cancer of unknown primary: clinicopathological study of CD34, VEGF and TSP-1
por: Karavasilis, Vasilis, et al.
Publicado: (2005)

IGFBP-3 reduces eNOS and PKCzeta phosphorylation, leading to lowered VEGF levels
por: Zhang, Qiuhua, et al.
Publicado: (2015)

Effects of Simulated Microgravity on Human Umbilical Vein Endothelial Cell Angiogenesis and Role of the PI3K-Akt-eNOS Signal Pathway
por: Shi, Fei, et al.
Publicado: (2012)

Molecular mechanisms underlying pharmacological stimulation of eNOS expression and eNOS activity
por: Li, Huige, et al.
Publicado: (2009)

The proliferation and angiogenesis in hemangioma-derived endothelial cells is affected by STC2 medicated VEGFR2/Akt/eNOS pathway
por: Ren, Shanshan, et al.
Publicado: (2023)

Correction: Tongxinluo protects against pressure overload-induced heart failure in mice involving VEGF/Akt/eNOS pathway activation
por: Wang, Bo, et al.
Publicado: (2019)

Basal Vascular Smooth Muscle Cell Tone in eNOS Knockout Mice Can Be Reversed by Cyclic Stretch and Is Independent of Age
por: De Moudt, Sofie, et al.
Publicado: (2022)

Arnebin-1 promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway
por: ZENG, ZHI, et al.
Publicado: (2015)

BET Bromodomain Suppression Inhibits VEGF-induced Angiogenesis and Vascular Permeability by Blocking VEGFR2-mediated Activation of PAK1 and eNOS
por: Huang, Mingcheng, et al.
Publicado: (2016)

Arnebin-1 promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway
por: Zeng, Zhi, et al.
Publicado: (2023)

Thyrotropin Regulates eNOS Expression in the Endothelium by PGRN Through Akt Pathway
por: Jiang, Fengwei, et al.
Publicado: (2018)

Pomegranate Juice Supplementation Alters Utero-Placental Vascular Function and Fetal Growth in the eNOS(−/−) Mouse Model of Fetal Growth Restriction
por: Finn-Sell, Sarah L., et al.
Publicado: (2018)

Role of the eNOS-NO System in Regulating the Antiproteinuric Effects of VEGF Receptor 2 Inhibition in Diabetes
por: Advani, Andrew, et al.
Publicado: (2013)

Podocyte VEGF-A Knockdown Induces Diffuse Glomerulosclerosis in Diabetic and in eNOS Knockout Mice
por: Veron, Delma, et al.
Publicado: (2022)

Rosuvastatin Enhances Angiogenesis via eNOS-Dependent Mobilization of Endothelial Progenitor Cells
por: Zhou, Junlan, et al.
Publicado: (2013)

Tiaojing Cuyun Recipe Enhances Pregnancy Outcome via the VEGF/PI3K/AKT/eNOS Signaling Pathway in EID Mice
por: Huang, Hongli, et al.
Publicado: (2022)

Activating CD137 Signaling Promotes Sprouting Angiogenesis via Increased VEGFA Secretion and the VEGFR2/Akt/eNOS Pathway
por: Li, Bo, et al.
Publicado: (2020)

Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway
por: Yu, Muyu, et al.
Publicado: (2020)

VEGF and eNOS Expression in Umbilical Cord from Pregnancy Complicated by Hypertensive Disorder with Different Severity
por: Bhavina, K., et al.
Publicado: (2014)

Circulating VEGF and eNOS variations as predictors of outcome in metastatic colorectal cancer patients receiving bevacizumab
por: Marisi, Giorgia, et al.
Publicado: (2017)

GPR87 Promotes Metastasis through the AKT-eNOS-NO Axis in Lung Adenocarcinoma
por: Ahn, Hye-Mi, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_mtgthhsj59lfaf5htujf5s7t4d