Cargando…

A Perspective on the Interplay of Ultraviolet-Radiation, Skin Microbiome and Skin Resident Memory TCRαβ+ Cells

The human skin is known to be inhabited by diverse microbes, including bacteria, fungi, viruses, archaea, and mites. This microbiome exerts a protective role against infections by promoting immune development and inhibiting pathogenic microbes to colonize skin. One of the factors having an intense e...

Descripción completa

Detalles Bibliográficos
Autores principales: Patra, VijayKumar, Laoubi, Léo, Nicolas, Jean-François, Vocanson, Marc, Wolf, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988872/
https://www.ncbi.nlm.nih.gov/pubmed/29900173
http://dx.doi.org/10.3389/fmed.2018.00166
_version_ 1783329366311174144
author Patra, VijayKumar
Laoubi, Léo
Nicolas, Jean-François
Vocanson, Marc
Wolf, Peter
author_facet Patra, VijayKumar
Laoubi, Léo
Nicolas, Jean-François
Vocanson, Marc
Wolf, Peter
author_sort Patra, VijayKumar
collection PubMed
description The human skin is known to be inhabited by diverse microbes, including bacteria, fungi, viruses, archaea, and mites. This microbiome exerts a protective role against infections by promoting immune development and inhibiting pathogenic microbes to colonize skin. One of the factors having an intense effect on the skin and its resident microbes is ultraviolet-radiation (UV-R). UV-R can promote or inhibit the growth of microbes on the skin and modulate the immune system which can be either favorable or harmful. Among potential UV-R targets, skin resident memory T cells (T(RM)) stand as well positioned immune cells at the forefront within the skin. Both CD4(+) or CD8(+) αβ T(RM) cells residing permanently in peripheral tissues have been shown to play prominent roles in providing accelerated and long-lived specific immunity, tissue homeostasis, wound repair. Nevertheless, their response upon UV-R exposure or signals from microbiome are poorly understood compared to resident TCRγδ cells. Skin T(RM) survive for long periods of time and are exposed to innumerable antigens during lifetime. The interplay of T(RM) with skin residing microbes may be crucial in pathophysiology of various diseases including psoriasis, atopic dermatitis and polymorphic light eruption. In this article, we share our perspective about how UV-R may directly shape the persistence, phenotype, specificity, and function of skin T(RM); and moreover, whether UV-R alters barrier function, leading to microbial-specific skin T(RM), disrupting the healthy balance between skin microbiome and skin immune cells, and resulting in chronic inflammation and diseased skin.
format Online
Article
Text
id pubmed-5988872
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-59888722018-06-13 A Perspective on the Interplay of Ultraviolet-Radiation, Skin Microbiome and Skin Resident Memory TCRαβ+ Cells Patra, VijayKumar Laoubi, Léo Nicolas, Jean-François Vocanson, Marc Wolf, Peter Front Med (Lausanne) Medicine The human skin is known to be inhabited by diverse microbes, including bacteria, fungi, viruses, archaea, and mites. This microbiome exerts a protective role against infections by promoting immune development and inhibiting pathogenic microbes to colonize skin. One of the factors having an intense effect on the skin and its resident microbes is ultraviolet-radiation (UV-R). UV-R can promote or inhibit the growth of microbes on the skin and modulate the immune system which can be either favorable or harmful. Among potential UV-R targets, skin resident memory T cells (T(RM)) stand as well positioned immune cells at the forefront within the skin. Both CD4(+) or CD8(+) αβ T(RM) cells residing permanently in peripheral tissues have been shown to play prominent roles in providing accelerated and long-lived specific immunity, tissue homeostasis, wound repair. Nevertheless, their response upon UV-R exposure or signals from microbiome are poorly understood compared to resident TCRγδ cells. Skin T(RM) survive for long periods of time and are exposed to innumerable antigens during lifetime. The interplay of T(RM) with skin residing microbes may be crucial in pathophysiology of various diseases including psoriasis, atopic dermatitis and polymorphic light eruption. In this article, we share our perspective about how UV-R may directly shape the persistence, phenotype, specificity, and function of skin T(RM); and moreover, whether UV-R alters barrier function, leading to microbial-specific skin T(RM), disrupting the healthy balance between skin microbiome and skin immune cells, and resulting in chronic inflammation and diseased skin. Frontiers Media S.A. 2018-05-30 /pmc/articles/PMC5988872/ /pubmed/29900173 http://dx.doi.org/10.3389/fmed.2018.00166 Text en Copyright © 2018 Patra, Laoubi, Nicolas, Vocanson and Wolf. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Patra, VijayKumar
Laoubi, Léo
Nicolas, Jean-François
Vocanson, Marc
Wolf, Peter
A Perspective on the Interplay of Ultraviolet-Radiation, Skin Microbiome and Skin Resident Memory TCRαβ+ Cells
title A Perspective on the Interplay of Ultraviolet-Radiation, Skin Microbiome and Skin Resident Memory TCRαβ+ Cells
title_full A Perspective on the Interplay of Ultraviolet-Radiation, Skin Microbiome and Skin Resident Memory TCRαβ+ Cells
title_fullStr A Perspective on the Interplay of Ultraviolet-Radiation, Skin Microbiome and Skin Resident Memory TCRαβ+ Cells
title_full_unstemmed A Perspective on the Interplay of Ultraviolet-Radiation, Skin Microbiome and Skin Resident Memory TCRαβ+ Cells
title_short A Perspective on the Interplay of Ultraviolet-Radiation, Skin Microbiome and Skin Resident Memory TCRαβ+ Cells
title_sort perspective on the interplay of ultraviolet-radiation, skin microbiome and skin resident memory tcrαβ+ cells
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988872/
https://www.ncbi.nlm.nih.gov/pubmed/29900173
http://dx.doi.org/10.3389/fmed.2018.00166
work_keys_str_mv AT patravijaykumar aperspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells
AT laoubileo aperspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells
AT nicolasjeanfrancois aperspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells
AT vocansonmarc aperspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells
AT wolfpeter aperspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells
AT patravijaykumar perspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells
AT laoubileo perspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells
AT nicolasjeanfrancois perspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells
AT vocansonmarc perspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells
AT wolfpeter perspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells