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Effects of leucovorin (folinic acid) in the methotrexate-treated rat brain

Folinic acid (FA) is generally administered to patients with CNS tumors in order to treat severe neurological disorders caused by methotrexate (MTX); therefore, we herein examined the effects of the co-administration of FA on MTX concentrations in the rat brain and cerebrospinal fluid (CSF) as well...

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Detalles Bibliográficos
Autores principales:	OGUSHI, Naofumi, SASAKI, Kazuaki, SHIMODA, Minoru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Japanese Society of Veterinary Science 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989019/ https://www.ncbi.nlm.nih.gov/pubmed/29607891 http://dx.doi.org/10.1292/jvms.17-0666

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