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Encephalitis induced by a newly discovered ruminant rhadinovirus in a free-living Formosan sambar deer (Rusa unicolor swinhoei)

We documented a case of a free-living Formosan sambar deer (Rusa unicolor swinhoei) infected with a newly discovered ruminant Rhadinovirus (RuRv). Non-purulent encephalitis was the primary histological lesion of the sambar deer. We conducted nested PCR to screen for herpesvirus using generic primers...

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Autores principales: CHANG, Ai-Mei, CHEN, Chen-Chih, CHANG, Ching-Dong, HUANG, Yen-Li, KE, Guan-Ming, WALTHER, Bruno Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989027/
https://www.ncbi.nlm.nih.gov/pubmed/29607882
http://dx.doi.org/10.1292/jvms.17-0477
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author CHANG, Ai-Mei
CHEN, Chen-Chih
CHANG, Ching-Dong
HUANG, Yen-Li
KE, Guan-Ming
WALTHER, Bruno Andreas
author_facet CHANG, Ai-Mei
CHEN, Chen-Chih
CHANG, Ching-Dong
HUANG, Yen-Li
KE, Guan-Ming
WALTHER, Bruno Andreas
author_sort CHANG, Ai-Mei
collection PubMed
description We documented a case of a free-living Formosan sambar deer (Rusa unicolor swinhoei) infected with a newly discovered ruminant Rhadinovirus (RuRv). Non-purulent encephalitis was the primary histological lesion of the sambar deer. We conducted nested PCR to screen for herpesvirus using generic primers targeting the DNA polymerase gene. In addition, we found that DNA polymerase gene of the sambar deer RuRv was present in the macrophage distributed in the Virchow Robin space with histopathologic lesions by chromogenic in-situ hybridization (CISH). The phylogenetic analysis indicated a high similarity between the viral sequence isolated from fallow deer and our case. This result suggests the possibility of cross-species transmission from other exotic Cervidae reservoir to the Formosan sambar deer.
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spelling pubmed-59890272018-06-08 Encephalitis induced by a newly discovered ruminant rhadinovirus in a free-living Formosan sambar deer (Rusa unicolor swinhoei) CHANG, Ai-Mei CHEN, Chen-Chih CHANG, Ching-Dong HUANG, Yen-Li KE, Guan-Ming WALTHER, Bruno Andreas J Vet Med Sci Wildlife Science We documented a case of a free-living Formosan sambar deer (Rusa unicolor swinhoei) infected with a newly discovered ruminant Rhadinovirus (RuRv). Non-purulent encephalitis was the primary histological lesion of the sambar deer. We conducted nested PCR to screen for herpesvirus using generic primers targeting the DNA polymerase gene. In addition, we found that DNA polymerase gene of the sambar deer RuRv was present in the macrophage distributed in the Virchow Robin space with histopathologic lesions by chromogenic in-situ hybridization (CISH). The phylogenetic analysis indicated a high similarity between the viral sequence isolated from fallow deer and our case. This result suggests the possibility of cross-species transmission from other exotic Cervidae reservoir to the Formosan sambar deer. The Japanese Society of Veterinary Science 2018-04-02 2018-05 /pmc/articles/PMC5989027/ /pubmed/29607882 http://dx.doi.org/10.1292/jvms.17-0477 Text en ©2018 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Wildlife Science
CHANG, Ai-Mei
CHEN, Chen-Chih
CHANG, Ching-Dong
HUANG, Yen-Li
KE, Guan-Ming
WALTHER, Bruno Andreas
Encephalitis induced by a newly discovered ruminant rhadinovirus in a free-living Formosan sambar deer (Rusa unicolor swinhoei)
title Encephalitis induced by a newly discovered ruminant rhadinovirus in a free-living Formosan sambar deer (Rusa unicolor swinhoei)
title_full Encephalitis induced by a newly discovered ruminant rhadinovirus in a free-living Formosan sambar deer (Rusa unicolor swinhoei)
title_fullStr Encephalitis induced by a newly discovered ruminant rhadinovirus in a free-living Formosan sambar deer (Rusa unicolor swinhoei)
title_full_unstemmed Encephalitis induced by a newly discovered ruminant rhadinovirus in a free-living Formosan sambar deer (Rusa unicolor swinhoei)
title_short Encephalitis induced by a newly discovered ruminant rhadinovirus in a free-living Formosan sambar deer (Rusa unicolor swinhoei)
title_sort encephalitis induced by a newly discovered ruminant rhadinovirus in a free-living formosan sambar deer (rusa unicolor swinhoei)
topic Wildlife Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989027/
https://www.ncbi.nlm.nih.gov/pubmed/29607882
http://dx.doi.org/10.1292/jvms.17-0477
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