Morphometric analysis of cornea in the Slc39a13/Zip13-knockout mice

Ehlers-Danlos syndrome (EDS) is a group of hereditary diseases caused by mutation of extracellular matrix-related genes. Recently, spondylodysplastic EDS-Zip13 (spEDS-Zip13: OMIM 612350) was recognized as a new EDS type. This current study could reveal various morphometric differences of collagenous...

Descripción completa

Detalles Bibliográficos
Autores principales: HIROSE, Takuya, SUZUKI, Ippei, TAKAHASHI, Naoki, FUKADA, Toshiyuki, TANGKAWATTANA, Prasarn, TAKEHANA, Kazushige
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2018
Materias:
Anatomy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989028/
https://www.ncbi.nlm.nih.gov/pubmed/29563392
http://dx.doi.org/10.1292/jvms.18-0019
Descripción
Sumario:Ehlers-Danlos syndrome (EDS) is a group of hereditary diseases caused by mutation of extracellular matrix-related genes. Recently, spondylodysplastic EDS-Zip13 (spEDS-Zip13: OMIM 612350) was recognized as a new EDS type. This current study could reveal various morphometric differences of collagenous population in the proper substance of cornea between the wild type and spEDS-Zip13-knockout (Zip13-KO) mice. Blockade of Smad-signaling pathway might initiate these alterations. Predilected dissimilarity in level of transcriptional activity probably dictated morphology of keratocyte and shape and electron density of its nucleus. In addition, the imbalance of proteoglycans and glycosaminoglycans would also affect the diameter and arrangement of collagen fibrils. These findings would be considered as vulnerable characteristics of corneal stroma of the Zip13-KO mice.

Ejemplares similares