Cargando…

Anti-myeloma Effects of Icariin Are Mediated Through the Attenuation of JAK/STAT3-Dependent Signaling Cascade

Because of the essential role of signal transducer and activator of transcription 3 (STAT3) in proliferation, anti-apoptosis, and chemoresistance of multiple myeloma (MM), we investigated whether icariin, a prenylated flavonol glycoside, inhibits both constitutive and inducible STAT3 activation in h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jung, Young Yun, Lee, Jong Hyun, Nam, Dongwoo, Narula, Acharan S., Namjoshi, Ojas A., Blough, Bruce E., Um, Jae-Young, Sethi, Gautam, Ahn, Kwang Seok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989039/ https://www.ncbi.nlm.nih.gov/pubmed/29899697 http://dx.doi.org/10.3389/fphar.2018.00531

Ejemplares similares

Oxymatrine Attenuates Tumor Growth and Deactivates STAT5 Signaling in a Lung Cancer Xenograft Model
por: Jung, Young Yun, et al.
Publicado: (2019)

2,3,5,6-Tetramethylpyrazine Targets Epithelial-Mesenchymal Transition by Abrogating Manganese Superoxide Dismutase Expression and TGFβ-Driven Signaling Cascades in Colon Cancer Cells
por: Jung, Young Yun, et al.
Publicado: (2022)

Identification of Matrine as a Novel Regulator of the CXCR4 Signaling Axis in Tumor Cells
por: Jung, Young Yun, et al.
Publicado: (2020)

Evodiamine Mitigates Cellular Growth and Promotes Apoptosis by Targeting the c-Met Pathway in Prostate Cancer Cells
por: Hwang, Sun Tae, et al.
Publicado: (2020)

Attenuation of STAT3 Signaling Cascade by Daidzin Can Enhance the Apoptotic Potential of Bortezomib against Multiple Myeloma
por: Yang, Min Hee, et al.
Publicado: (2019)

Bergamottin Suppresses Metastasis of Lung Cancer Cells through Abrogation of Diverse Oncogenic Signaling Cascades and Epithelial-to-Mesenchymal Transition
por: Ko, Jeong-Hyeon, et al.
Publicado: (2018)

Fangchinoline diminishes STAT3 activation by stimulating oxidative stress and targeting SHP-1 protein in multiple myeloma model
por: Jung, Young Yun, et al.
Publicado: (2021)

Capsazepine inhibits JAK/STAT3 signaling, tumor growth, and cell survival in prostate cancer
por: Lee, Jong Hyun, et al.
Publicado: (2016)

Euphorbiasteroid Induces Apoptosis as Well as Autophagy through Modulating SHP-1/STAT3 Pathway in Hepatocellular Carcinoma Cells
por: Kim, Na Young, et al.
Publicado: (2023)

Casticin-Induced Inhibition of Cell Growth and Survival Are Mediated through the Dual Modulation of Akt/mTOR Signaling Cascade
por: Lee, Jong Hyun, et al.
Publicado: (2019)

Leelamine Modulates STAT5 Pathway Causing Both Autophagy and Apoptosis in Chronic Myelogenous Leukemia Cells
por: Jung, Young Yun, et al.
Publicado: (2022)

A Novel Role of Bergamottin in Attenuating Cancer Associated Cachexia by Diverse Molecular Mechanisms
por: Jung, Young Yun, et al.
Publicado: (2021)

JAK/STAT and Hox Dynamic Interactions in an Organogenetic Gene Cascade
por: Pinto, Pedro B., et al.
Publicado: (2015)

Genetic alterations of JAK/STAT cascade and histone modification in extranodal NK/T-cell lymphoma nasal type
por: Lee, Seungbok, et al.
Publicado: (2015)

Ophiopogonin D, a Steroidal Glycoside Abrogates STAT3 Signaling Cascade and Exhibits Anti-Cancer Activity by Causing GSH/GSSG Imbalance in Lung Carcinoma
por: Lee, Jong Hyun, et al.
Publicado: (2018)

Brusatol, a Nrf2 Inhibitor Targets STAT3 Signaling Cascade in Head and Neck Squamous Cell Carcinoma
por: Lee, Jong Hyun, et al.
Publicado: (2019)

Formononetin Regulates Multiple Oncogenic Signaling Cascades and Enhances Sensitivity to Bortezomib in a Multiple Myeloma Mouse Model
por: Kim, Chulwon, et al.
Publicado: (2019)

Resveratrol attenuates constitutive STAT3 and STAT5 activation through induction of PTPε and SHP-2 tyrosine phosphatases and potentiates sorafenib-induced apoptosis in renal cell carcinoma
por: Kim, Chulwon, et al.
Publicado: (2016)

Potential Application of Leelamine as a Novel Regulator of Chemokine-Induced Epithelial-to-Mesenchymal Transition in Breast Cancer Cells
por: Jung, Young Yun, et al.
Publicado: (2022)

The natural analgesic conolidine targets the newly identified opioid scavenger ACKR3/CXCR7
por: Szpakowska, Martyna, et al.
Publicado: (2021)

Albendazole Exhibits Anti-Neoplastic Actions against Gastric Cancer Cells by Affecting STAT3 and STAT5 Activation by Pleiotropic Mechanism(s)
por: Yang, Min Hee, et al.
Publicado: (2021)

Icaritin suppresses multiple myeloma, by inhibiting IL-6/JAK2/STAT3
por: Zhu, Shicong, et al.
Publicado: (2015)

Sinomenine attenuates cancer-induced bone pain via suppressing microglial JAK2/STAT3 and neuronal CAMKII/CREB cascades in rat models
por: Chen, Shu-Ping, et al.
Publicado: (2018)

2,5-Dihydroxyacetophenone Induces Apoptosis of Multiple Myeloma Cells by Regulating the MAPK Activation Pathway
por: Ko, Jeong-Hyeon, et al.
Publicado: (2017)

JAKs and STATs in chemoresistance
por: Costa-Pereira, Ana P
Publicado: (2010)

JAK-STAT and feeding
por: Ladyman, Sharon R., et al.
Publicado: (2013)

Berbamine Analogs Exhibit Differential Protective Effects From Aminoglycoside-Induced Hair Cell Death
por: Hudson, Alexandria M., et al.
Publicado: (2020)

The role of the JAK-STAT pathway and related signal cascades in telomerase activation during the development of hematologic malignancies
por: Yamada, Osamu, et al.
Publicado: (2013)

JAK2/STAT3 Inhibition Attenuates Noise-Induced Hearing Loss
por: Wilson, Teresa, et al.
Publicado: (2014)

Curcumol Attenuates Endometriosis by Inhibiting the JAK2/STAT3 Signaling Pathway
por: Wang, Yan, et al.
Publicado: (2022)

TNFα Mediated IL-6 Secretion Is Regulated by JAK/STAT Pathway but Not by MEK Phosphorylation and AKT Phosphorylation in U266 Multiple Myeloma Cells
por: Lee, Chansu, et al.
Publicado: (2013)

Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma
por: Shanmugam, Muthu K., et al.
Publicado: (2018)

CEP55 Promotes Cell Motility via JAK2–STAT3–MMPs Cascade in Hepatocellular Carcinoma
por: Li, Minjing, et al.
Publicado: (2018)

A JAK/STAT invasion
por: Wells, William A.
Publicado: (2002)

JAK-STAT and bone metabolism
por: Li, Jiliang
Publicado: (2013)

The Drosophila JAK-STAT pathway
por: Zeidler, Martin P, et al.
Publicado: (2013)

Evolution of the JAK-STAT pathway
por: Liongue, Clifford, et al.
Publicado: (2013)

The JAK-STAT pathway at 20
por: Darnell, Jr., James E.
Publicado: (2012)

JAK-STAT in lymphoproliferative disorders
por: Rabadan, Raul, et al.
Publicado: (2015)

Vanillic acid attenuates testosterone-induced benign prostatic hyperplasia in rats and inhibits proliferation of prostatic epithelial cells
por: Jung, Yunu, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_9kajnqi33mckehpu83r4hptihi