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Inverse Perfusion Requirements of Supra- and Infratentorial Brain Metastases Formation
Background and Aims: Vascular border zones and the gray-white matter junction are preferred sites for the development of brain metastases (BM), whereas microvascular lesions are known to be a protective factor. In this proof of concept study, we aim to study the relationship of blood perfusion and t...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989059/ https://www.ncbi.nlm.nih.gov/pubmed/29899729 http://dx.doi.org/10.3389/fneur.2018.00391 |
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author | Schneider, Tanja Kemmling, André Schroeder, Julian Pantel, Klaus Glatzel, Markus Schoen, Gerhard Mohme, Malte Fiehler, Jens Gellißen, Susanne |
author_facet | Schneider, Tanja Kemmling, André Schroeder, Julian Pantel, Klaus Glatzel, Markus Schoen, Gerhard Mohme, Malte Fiehler, Jens Gellißen, Susanne |
author_sort | Schneider, Tanja |
collection | PubMed |
description | Background and Aims: Vascular border zones and the gray-white matter junction are preferred sites for the development of brain metastases (BM), whereas microvascular lesions are known to be a protective factor. In this proof of concept study, we aim to study the relationship of blood perfusion and the spatial distribution of BM. Materials and Methods: An average CT perfusion atlas of 107 healthy patients was created. Voxel-wise reference perfusion values were extracted from BM-negative and BM-positive regions in a second cohort of 100 untreated patients harboring 809 BM confirmed by MRI. A comparison of regional perfusion values was performed using the independent t-test. Results: In contrast to supratentorial BM that develop preferably in areas with lower CBV/CBF and longer MTT/TTP compared to the average regional perfusion (p < 0.001), infratentorial BM showed a higher CBV/CBF and shorter MTT/TTP (p < 0.001). Conclusion: Our results imply differing pathophysiological mechanisms underlying supra- and infratentorial BM spreading. The inverse perfusion patterns may result from differences in vascular supply, hemodynamic requirements, and/or production of pro-angiogenic factors. |
format | Online Article Text |
id | pubmed-5989059 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59890592018-06-13 Inverse Perfusion Requirements of Supra- and Infratentorial Brain Metastases Formation Schneider, Tanja Kemmling, André Schroeder, Julian Pantel, Klaus Glatzel, Markus Schoen, Gerhard Mohme, Malte Fiehler, Jens Gellißen, Susanne Front Neurol Neurology Background and Aims: Vascular border zones and the gray-white matter junction are preferred sites for the development of brain metastases (BM), whereas microvascular lesions are known to be a protective factor. In this proof of concept study, we aim to study the relationship of blood perfusion and the spatial distribution of BM. Materials and Methods: An average CT perfusion atlas of 107 healthy patients was created. Voxel-wise reference perfusion values were extracted from BM-negative and BM-positive regions in a second cohort of 100 untreated patients harboring 809 BM confirmed by MRI. A comparison of regional perfusion values was performed using the independent t-test. Results: In contrast to supratentorial BM that develop preferably in areas with lower CBV/CBF and longer MTT/TTP compared to the average regional perfusion (p < 0.001), infratentorial BM showed a higher CBV/CBF and shorter MTT/TTP (p < 0.001). Conclusion: Our results imply differing pathophysiological mechanisms underlying supra- and infratentorial BM spreading. The inverse perfusion patterns may result from differences in vascular supply, hemodynamic requirements, and/or production of pro-angiogenic factors. Frontiers Media S.A. 2018-05-30 /pmc/articles/PMC5989059/ /pubmed/29899729 http://dx.doi.org/10.3389/fneur.2018.00391 Text en Copyright © 2018 Schneider, Kemmling, Schroeder, Pantel, Glatzel, Schoen, Mohme, Fiehler and Gellißen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Schneider, Tanja Kemmling, André Schroeder, Julian Pantel, Klaus Glatzel, Markus Schoen, Gerhard Mohme, Malte Fiehler, Jens Gellißen, Susanne Inverse Perfusion Requirements of Supra- and Infratentorial Brain Metastases Formation |
title | Inverse Perfusion Requirements of Supra- and Infratentorial Brain Metastases Formation |
title_full | Inverse Perfusion Requirements of Supra- and Infratentorial Brain Metastases Formation |
title_fullStr | Inverse Perfusion Requirements of Supra- and Infratentorial Brain Metastases Formation |
title_full_unstemmed | Inverse Perfusion Requirements of Supra- and Infratentorial Brain Metastases Formation |
title_short | Inverse Perfusion Requirements of Supra- and Infratentorial Brain Metastases Formation |
title_sort | inverse perfusion requirements of supra- and infratentorial brain metastases formation |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989059/ https://www.ncbi.nlm.nih.gov/pubmed/29899729 http://dx.doi.org/10.3389/fneur.2018.00391 |
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