Cargando…

DDX41 Recognizes RNA/DNA Retroviral Reverse Transcripts and Is Critical for In Vivo Control of Murine Leukemia Virus Infection

Host recognition of viral nucleic acids generated during infection leads to the activation of innate immune responses essential for early control of virus. Retrovirus reverse transcription creates numerous potential ligands for cytosolic host sensors that recognize foreign nucleic acids, including s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stavrou, Spyridon, Aguilera, Alexya N., Blouch, Kristin, Ross, Susan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989071/ https://www.ncbi.nlm.nih.gov/pubmed/29871919 http://dx.doi.org/10.1128/mBio.00923-18

Ejemplares similares

DDX41 is required for cGAS-STING activation against DNA virus infection
por: Singh, Ravi Shankar, et al.
Publicado: (2022)

Different Modes of Retrovirus Restriction by Human APOBEC3A and APOBEC3G In Vivo
por: Stavrou, Spyridon, et al.
Publicado: (2014)

Observation and treatment in DDX41-mutated acute myeloid leukemia and myelodysplastic syndrome
por: Al-Kali, Aref, et al.
Publicado: (2023)

DDX41-associated susceptibility to myeloid neoplasms
por: Makishima, Hideki, et al.
Publicado: (2023)

Germline heterozygous DDX41 variants in a subset of familial myelodysplasia and acute myeloid leukemia
por: Cardoso, S R, et al.
Publicado: (2016)

Outcomes of allogeneic transplant in patients with DDX41 mutated myelodysplastic syndrome and acute myeloid leukemia
por: Baranwal, Anmol, et al.
Publicado: (2022)

Biallelic disruption of DDX41 activity is associated with distinct genomic and immunophenotypic hallmarks in acute leukemia
por: Tierens, Anne, et al.
Publicado: (2023)

The emerging roles of the DDX41 protein in immunity and diseases
por: Jiang, Yan, et al.
Publicado: (2016)

Current Understanding of DDX41 Mutations in Myeloid Neoplasms
por: Kim, Kunhwa, et al.
Publicado: (2023)

DDX41 is needed for pre- and postnatal hematopoietic stem cell differentiation in mice
por: Ma, Jing, et al.
Publicado: (2022)

A novel bi-alleleic DDX41 mutations in B-cell lymphoblastic leukemia: case report
por: Shin, Woo Yong, et al.
Publicado: (2022)

Next‐generation sequencing reveals the presence of DDX41 mutations in acute lymphoblastic leukemia and aplastic anemia
por: Zhang, Yang, et al.
Publicado: (2021)

Structural and functional analyses of human DDX41 DEAD domain
por: Jiang, Yan, et al.
Publicado: (2016)

DDX41 recognizes bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response
por: Parvatiyar, Kislay, et al.
Publicado: (2012)

Murine Leukemias with Retroviral Insertions at Lmo2 Are Predictive of the Leukemias Induced in SCID-X1 Patients Following Retroviral Gene Therapy
por: Davé, Utpal P., et al.
Publicado: (2009)

Erratum to: Structural and functional analyses of human DDX41 DEAD domain
por: Jiang, Yan, et al.
Publicado: (2017)

Are DDX41 variants of unknown significance and pathogenic variants created equal?
por: Xie, Zhuoer, et al.
Publicado: (2023)

In Vitro Murine Leukemia Retroviral Integration and Structure Fluctuation of Target DNA
por: Tsuruyama, Tatsuaki, et al.
Publicado: (2012)

Unique ethnic features of DDX41 mutations in patients with idiopathic cytopenia of undetermined significance, myelodysplastic syndrome, or acute myeloid leukemia
por: Choi, Eun-Ji, et al.
Publicado: (2021)

Favorable outcomes of DDX41‐mutated myelodysplastic syndrome and low blast count acute myeloid leukemia treated with azacitidine ± lenalidomide
por: Tiong, Ing S., et al.
Publicado: (2023)

The DEAD-box RNA Helicase DDX6 is Required for Efficient Encapsidation of a Retroviral Genome
por: Yu, Shuyuarn F., et al.
Publicado: (2011)

Ddx41 inhibition of DNA damage signaling permits erythroid progenitor expansion in zebrafish
por: Weinreb, Joshua T., et al.
Publicado: (2021)

DDX41 regulates the expression and alternative splicing of genes involved in tumorigenesis and immune response
por: Qin, Kai, et al.
Publicado: (2021)

P442: DDX41 GERMLINE VARIANTS: POPULATION PREVALENCE, SIGNIFICANCE AND LEUKEMIC EVOLUTION
por: Cheloor Kovilakam, Sruthi, et al.
Publicado: (2023)

Level of Murine DDX3 RNA Helicase Determines Phenotype Changes of Hepatocytes In Vitro and In Vivo
por: Sergeeva, Olga, et al.
Publicado: (2021)

Characterization of monoclonal antibodies recognizing neurotropic Friend murine leukemia virus
por: Ikeda, Tomio, et al.
Publicado: (1995)

Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide
por: Omura, Hiroki, et al.
Publicado: (2016)

Genetic features and clinical outcomes of patients with isolated and comutated DDX41-mutated myeloid neoplasms
por: Alkhateeb, Hassan B., et al.
Publicado: (2022)

Next-Generation Sequencing of DDX41 in Myeloid Neoplasms Leads to Increased Detection of Germline Alterations
por: Bannon, Sarah A., et al.
Publicado: (2021)

Unique role of DDX41, a DEAD-box type RNA helicase, in hematopoiesis and leukemogenesis
por: Shinriki, Satoru, et al.
Publicado: (2022)

Clinical and molecular correlates of somatic and germline DDX41 variants in patients and families with myeloid neoplasms
por: Badar, Talha, et al.
Publicado: (2023)

MEF2A suppresses stress responses that trigger DDX41-dependent IFN production
por: Smith, Julian R., et al.
Publicado: (2023)

Endogenous murine leukemia retroviral variation across wild European and inbred strains of house mouse
por: Hartmann, Stefanie, et al.
Publicado: (2015)

DDX41 germline variants causing donor cell leukemia indicate a need for further genetic workup in the context of hematopoietic stem cell transplantation
por: Rolles, Benjamin, et al.
Publicado: (2023)

PB1819: KMT2A::ARHGEF12 RARE FUSION ASSOCIATED WITH A NOVEL GERMLINE DDX41 VARIANT IN ACUTE MYELOID LEUKEMIA
por: Roubinet, Maxime, et al.
Publicado: (2023)

Clinical features of DDX41 mutation-related diseases: a systematic review with individual patient data
por: Wan, Ziqi, et al.
Publicado: (2021)

R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability
por: Mosler, Thorsten, et al.
Publicado: (2021)

DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells
por: Shinriki, Satoru, et al.
Publicado: (2022)

Implications of the Nucleocapsid and the Microenvironment in Retroviral Reverse Transcription
por: Mougel, Marylène, et al.
Publicado: (2010)

Insights into the Involvement of Spliceosomal Mutations in Myelodysplastic Disorders from Analysis of SACY-1/DDX41 in Caenorhabditis elegans
por: Tsukamoto, Tatsuya, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ba325qrm57b6t77ld7v660uk25