DNA sequence features in the establishing of H3K27ac

The presence of H3K27me3 has been demonstrated to correlate with the CpG content. In this work, we tested whether H3K27ac has similar sequence preferences. We performed a translocation of DNA sequences with various properties into a beta-globin locus to control for the local chromatin environment. O...

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Detalles Bibliográficos
Autores principales: Zubritskiy, Anatoliy, Medvedeva, Yulia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2018
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989146/
https://www.ncbi.nlm.nih.gov/pubmed/29904589
http://dx.doi.org/10.12688/f1000research.13441.2
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author Zubritskiy, Anatoliy
Medvedeva, Yulia A.
author_facet Zubritskiy, Anatoliy
Medvedeva, Yulia A.
author_sort Zubritskiy, Anatoliy
collection PubMed
description The presence of H3K27me3 has been demonstrated to correlate with the CpG content. In this work, we tested whether H3K27ac has similar sequence preferences. We performed a translocation of DNA sequences with various properties into a beta-globin locus to control for the local chromatin environment. Our results suggest that in contrast to H3K27me3, H3K27ac gain is unlikely affected by the CpG content of the underlying DNA sequence, while extremely high GC-content might contribute to the gain of the H3K27ac.
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spelling pubmed-59891462018-06-13 DNA sequence features in the establishing of H3K27ac Zubritskiy, Anatoliy Medvedeva, Yulia A. F1000Res Research Note The presence of H3K27me3 has been demonstrated to correlate with the CpG content. In this work, we tested whether H3K27ac has similar sequence preferences. We performed a translocation of DNA sequences with various properties into a beta-globin locus to control for the local chromatin environment. Our results suggest that in contrast to H3K27me3, H3K27ac gain is unlikely affected by the CpG content of the underlying DNA sequence, while extremely high GC-content might contribute to the gain of the H3K27ac. F1000 Research Limited 2018-08-09 /pmc/articles/PMC5989146/ /pubmed/29904589 http://dx.doi.org/10.12688/f1000research.13441.2 Text en Copyright: © 2018 Zubritskiy A and Medvedeva YA http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Note
Zubritskiy, Anatoliy
Medvedeva, Yulia A.
DNA sequence features in the establishing of H3K27ac
title DNA sequence features in the establishing of H3K27ac
title_full DNA sequence features in the establishing of H3K27ac
title_fullStr DNA sequence features in the establishing of H3K27ac
title_full_unstemmed DNA sequence features in the establishing of H3K27ac
title_short DNA sequence features in the establishing of H3K27ac
title_sort dna sequence features in the establishing of h3k27ac
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989146/
https://www.ncbi.nlm.nih.gov/pubmed/29904589
http://dx.doi.org/10.12688/f1000research.13441.2
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