SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub

SETBP1 variants occur as somatic mutations in several hematological malignancies such as atypical chronic myeloid leukemia and as de novo germline mutations in the Schinzel–Giedion syndrome. Here we show that SETBP1 binds to gDNA in AT-rich promoter regions, causing activation of gene expression thr...

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Detalles Bibliográficos
Autores principales: Piazza, Rocco, Magistroni, Vera, Redaelli, Sara, Mauri, Mario, Massimino, Luca, Sessa, Alessandro, Peronaci, Marco, Lalowski, Maciej, Soliymani, Rabah, Mezzatesta, Caterina, Pirola, Alessandra, Banfi, Federica, Rubio, Alicia, Rea, Delphine, Stagno, Fabio, Usala, Emilio, Martino, Bruno, Campiotti, Leonardo, Merli, Michele, Passamonti, Francesco, Onida, Francesco, Morotti, Alessandro, Pavesi, Francesca, Bregni, Marco, Broccoli, Vania, Baumann, Marc, Gambacorti-Passerini, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989213/
https://www.ncbi.nlm.nih.gov/pubmed/29875417
http://dx.doi.org/10.1038/s41467-018-04462-8

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