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Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA
Hepatitis B virus (HBV) is still a worldwide health concern. While divergent factors are involved in its pathogenesis, it is now clear that HBV RNAs, principally templates for viral proteins and viral DNAs, have diverse biological functions involved in HBV pathogenesis. These functions include viral...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989240/ https://www.ncbi.nlm.nih.gov/pubmed/29881235 http://dx.doi.org/10.3748/wjg.v24.i21.2261 |
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author | Sekiba, Kazuma Otsuka, Motoyuki Ohno, Motoko Yamagami, Mari Kishikawa, Takahiro Suzuki, Tatsunori Ishibashi, Rei Seimiya, Takahiro Tanaka, Eri Koike, Kazuhiko |
author_facet | Sekiba, Kazuma Otsuka, Motoyuki Ohno, Motoko Yamagami, Mari Kishikawa, Takahiro Suzuki, Tatsunori Ishibashi, Rei Seimiya, Takahiro Tanaka, Eri Koike, Kazuhiko |
author_sort | Sekiba, Kazuma |
collection | PubMed |
description | Hepatitis B virus (HBV) is still a worldwide health concern. While divergent factors are involved in its pathogenesis, it is now clear that HBV RNAs, principally templates for viral proteins and viral DNAs, have diverse biological functions involved in HBV pathogenesis. These functions include viral replication, hepatic fibrosis and hepatocarcinogenesis. Depending on the sequence similarities, HBV RNAs may act as sponges for host miRNAs and may deregulate miRNA functions, possibly leading to pathological consequences. Some parts of the HBV RNA molecule may function as viral-derived miRNA, which regulates viral replication. HBV DNA can integrate into the host genomic DNA and produce novel viral-host fusion RNA, which may have pathological functions. To date, elimination of HBV-derived covalently closed circular DNA has not been achieved. However, RNA transcription silencing may be an alternative practical approach to treat HBV-induced pathogenesis. A full understanding of HBV RNA transcription and the biological functions of HBV RNA may open a new avenue for the development of novel HBV therapeutics. |
format | Online Article Text |
id | pubmed-5989240 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-59892402018-06-08 Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA Sekiba, Kazuma Otsuka, Motoyuki Ohno, Motoko Yamagami, Mari Kishikawa, Takahiro Suzuki, Tatsunori Ishibashi, Rei Seimiya, Takahiro Tanaka, Eri Koike, Kazuhiko World J Gastroenterol Minireviews Hepatitis B virus (HBV) is still a worldwide health concern. While divergent factors are involved in its pathogenesis, it is now clear that HBV RNAs, principally templates for viral proteins and viral DNAs, have diverse biological functions involved in HBV pathogenesis. These functions include viral replication, hepatic fibrosis and hepatocarcinogenesis. Depending on the sequence similarities, HBV RNAs may act as sponges for host miRNAs and may deregulate miRNA functions, possibly leading to pathological consequences. Some parts of the HBV RNA molecule may function as viral-derived miRNA, which regulates viral replication. HBV DNA can integrate into the host genomic DNA and produce novel viral-host fusion RNA, which may have pathological functions. To date, elimination of HBV-derived covalently closed circular DNA has not been achieved. However, RNA transcription silencing may be an alternative practical approach to treat HBV-induced pathogenesis. A full understanding of HBV RNA transcription and the biological functions of HBV RNA may open a new avenue for the development of novel HBV therapeutics. Baishideng Publishing Group Inc 2018-06-07 2018-06-07 /pmc/articles/PMC5989240/ /pubmed/29881235 http://dx.doi.org/10.3748/wjg.v24.i21.2261 Text en ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Minireviews Sekiba, Kazuma Otsuka, Motoyuki Ohno, Motoko Yamagami, Mari Kishikawa, Takahiro Suzuki, Tatsunori Ishibashi, Rei Seimiya, Takahiro Tanaka, Eri Koike, Kazuhiko Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA |
title | Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA |
title_full | Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA |
title_fullStr | Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA |
title_full_unstemmed | Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA |
title_short | Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA |
title_sort | hepatitis b virus pathogenesis: fresh insights into hepatitis b virus rna |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989240/ https://www.ncbi.nlm.nih.gov/pubmed/29881235 http://dx.doi.org/10.3748/wjg.v24.i21.2261 |
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