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Age-specific effects of structural and functional connectivity in prefrontal-amygdala circuitry in women with bipolar disorder

BACKGROUND: Bipolar disorder (BD) is a serious mental illness. Several studies have shown that brain structure and function changes and the development of BD are associated with age and sex differences. Therefore, we hypothesized that the functional and structural neural circuitry of BD patients wou...

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Autores principales: Tang, Yanqing, Ma, Yinzhu, Chen, Xuemei, Fan, Xuesheng, Jiang, Xiaowei, Zhou, Yifang, Wang, Fei, Wei, Shengnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989351/
https://www.ncbi.nlm.nih.gov/pubmed/29871591
http://dx.doi.org/10.1186/s12888-018-1732-9
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author Tang, Yanqing
Ma, Yinzhu
Chen, Xuemei
Fan, Xuesheng
Jiang, Xiaowei
Zhou, Yifang
Wang, Fei
Wei, Shengnan
author_facet Tang, Yanqing
Ma, Yinzhu
Chen, Xuemei
Fan, Xuesheng
Jiang, Xiaowei
Zhou, Yifang
Wang, Fei
Wei, Shengnan
author_sort Tang, Yanqing
collection PubMed
description BACKGROUND: Bipolar disorder (BD) is a serious mental illness. Several studies have shown that brain structure and function changes and the development of BD are associated with age and sex differences. Therefore, we hypothesized that the functional and structural neural circuitry of BD patients would differ according to age. The amygdala and prefrontal cortex (PFC) are play a key role in the emotional and cognitive processing of patients with BD. In this study, we used magnetic resonance imaging (MRI) to examine the structural and functional connectivity within amygdala-PFC neural circuitry in women with BD at different ages. METHODS: Forty-nine female patients with BD who were aged 13–25 years and 60 age-matched healthy control (HC) individuals, as well as 43 female patients with BD who were aged 26–45 years and 60 age-matched HC individuals underwent resting-state functional MRI (rs-fMRI) and diffusion tensor imaging to examine the structural and functional connectivity within the amygdala-PFC neural circuitry. RESULTS: We found abnormalities in the amygdala-PFC functional connectivity in patients aged 13–25 years and significantly different fractional anisotropy (FA) values in patients aged 26–45 compared with the age-matched HCs. The significance of these findings was indicated by corrected p values of less than 0.05 (uncorrected p values less than 0.001). CONCLUSIONS: The findings in this cross-sectional study suggested that abnormalities in the functional connectivity of the amygdala-PFC neural circuitry are related to the pathophysiology of BD in women aged 13–25 years, while changes in the structural integrity of this neural circuitry are associated with the pathophysiology of BD in women aged 26–45 years. Therefore, functional and structural brain alterations may occur at different ages in female patients with BD. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12888-018-1732-9) contains supplementary material, which is available to authorized users.
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spelling pubmed-59893512018-06-20 Age-specific effects of structural and functional connectivity in prefrontal-amygdala circuitry in women with bipolar disorder Tang, Yanqing Ma, Yinzhu Chen, Xuemei Fan, Xuesheng Jiang, Xiaowei Zhou, Yifang Wang, Fei Wei, Shengnan BMC Psychiatry Research Article BACKGROUND: Bipolar disorder (BD) is a serious mental illness. Several studies have shown that brain structure and function changes and the development of BD are associated with age and sex differences. Therefore, we hypothesized that the functional and structural neural circuitry of BD patients would differ according to age. The amygdala and prefrontal cortex (PFC) are play a key role in the emotional and cognitive processing of patients with BD. In this study, we used magnetic resonance imaging (MRI) to examine the structural and functional connectivity within amygdala-PFC neural circuitry in women with BD at different ages. METHODS: Forty-nine female patients with BD who were aged 13–25 years and 60 age-matched healthy control (HC) individuals, as well as 43 female patients with BD who were aged 26–45 years and 60 age-matched HC individuals underwent resting-state functional MRI (rs-fMRI) and diffusion tensor imaging to examine the structural and functional connectivity within the amygdala-PFC neural circuitry. RESULTS: We found abnormalities in the amygdala-PFC functional connectivity in patients aged 13–25 years and significantly different fractional anisotropy (FA) values in patients aged 26–45 compared with the age-matched HCs. The significance of these findings was indicated by corrected p values of less than 0.05 (uncorrected p values less than 0.001). CONCLUSIONS: The findings in this cross-sectional study suggested that abnormalities in the functional connectivity of the amygdala-PFC neural circuitry are related to the pathophysiology of BD in women aged 13–25 years, while changes in the structural integrity of this neural circuitry are associated with the pathophysiology of BD in women aged 26–45 years. Therefore, functional and structural brain alterations may occur at different ages in female patients with BD. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12888-018-1732-9) contains supplementary material, which is available to authorized users. BioMed Central 2018-06-05 /pmc/articles/PMC5989351/ /pubmed/29871591 http://dx.doi.org/10.1186/s12888-018-1732-9 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Tang, Yanqing
Ma, Yinzhu
Chen, Xuemei
Fan, Xuesheng
Jiang, Xiaowei
Zhou, Yifang
Wang, Fei
Wei, Shengnan
Age-specific effects of structural and functional connectivity in prefrontal-amygdala circuitry in women with bipolar disorder
title Age-specific effects of structural and functional connectivity in prefrontal-amygdala circuitry in women with bipolar disorder
title_full Age-specific effects of structural and functional connectivity in prefrontal-amygdala circuitry in women with bipolar disorder
title_fullStr Age-specific effects of structural and functional connectivity in prefrontal-amygdala circuitry in women with bipolar disorder
title_full_unstemmed Age-specific effects of structural and functional connectivity in prefrontal-amygdala circuitry in women with bipolar disorder
title_short Age-specific effects of structural and functional connectivity in prefrontal-amygdala circuitry in women with bipolar disorder
title_sort age-specific effects of structural and functional connectivity in prefrontal-amygdala circuitry in women with bipolar disorder
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989351/
https://www.ncbi.nlm.nih.gov/pubmed/29871591
http://dx.doi.org/10.1186/s12888-018-1732-9
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